DegronMD

Uniprot ID: Q9ULZ2

Source protein: Signal-transducing adaptor protein 1

Source gene: STAP1

Class: LIG_APCC_ABBA_1

Location: 24:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8499

ASA_SCORE: 47.7

COIL: 0.5002

CONS_SCORE: 0.8507

DSS_SCORE: 0.021

HELIX: 0.0112

FCONS_SCORE: 1.1918

RIG_SCORE: 0.9255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L24I	TCGA-2Z-A9J8	KIRP	TCGA	LPLYFE	LIG_APCC_ABBA_1	0.6063
p.L24I	DO219660	KIRP	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.6063
p.K20N	TCGA-A5-A0G1	UCEC	TCGA	LPLYFE	LIG_APCC_ABBA_1	0.3333
p.K20N	DO42472	UCEC	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.3333
p.A23D	TCGA-A5-A0G1	UCEC	TCGA	LPLYFE	LIG_APCC_ABBA_1	0.3056
p.A23D	DO42472	UCEC	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.3056
p.E17K	TCGA-D3-A3ML	SKCM	TCGA	LPLYFE	LIG_APCC_ABBA_1	0.1389
p.E17K	DO47413	SKCM	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.1389
p.G38E	TCGA-FW-A3R5	SKCM	TCGA	LPLYFE	LIG_APCC_ABBA_1	0.0833
p.G38E	DO37406	SKCM	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.0833
p.R36Q	DO871	BOCA	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.1389
p.I14F	DO233739	GACA	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.0556
p.A23S	DO229025	LICA	ICGC	LPLYFE	LIG_APCC_ABBA_1	0.3056
p.I34M	SIDM00806	Osteosarcoma	GDSC	LPLYFE	LIG_APCC_ABBA_1	0.1944
p.I34M	HOS	bone	COSMIC	LPLYFE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULZ2	Signal-transducing adaptor protein 1	LIG_APCC_ABBA_1	24:29	LPLYFE	APC,CDC20,FZR1	0.8499	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons