DegronMD

Uniprot ID: Q3B820

Source protein: Protein FAM161A

Source gene: FAM161A

Class: LIG_APCC_ABBA_1

Location: 293:298

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8444

ASA_SCORE: 78.2167

COIL: 0.389

CONS_SCORE: 0.7072

DSS_SCORE: 0.3832

HELIX: 0.5958

FCONS_SCORE: 1.0739

RIG_SCORE: 0.8332

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R306W	TCGA-75-5126	LUAD	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	TCGA-AP-A051	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	TCGA-AP-A0LG	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	DO23711	LUAD	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	DO41823	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	DO42673	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306W	SIDM01145	Gastric Carcinoma	GDSC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.P288T	TCGA-AY-6197	COAD	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.1944
p.P288T	DO9956	COAD	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.1944
p.R307I	TCGA-DF-A2KU	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.0833
p.R307I	DO223286	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.0833
p.K301N	TCGA-EO-A22R	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.3611
p.K301N	DO42713	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.3611
p.K301R	TCGA-GL-A59R	KIRP	TCGA	LPLYHD	LIG_APCC_ABBA_1	0.3611
p.K301R	DO44525	KIRP	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.3611
p.P294L	DO228313	LICA	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.6471
p.V287F	DO228667	LICA	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.1667
p.A284S	DO231047	LUSC	ICGC	LPLYHD	LIG_APCC_ABBA_1	0.0833
p.R306Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306Q	ACH-000960	Leukemia	CCLE	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R306Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	LPLYHD	LIG_APCC_ABBA_1	0.1111
p.R283Q	ACH-000833	Sarcoma	CCLE	LPLYHD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3B820	Protein FAM161A	LIG_APCC_ABBA_1	293:298	LPLYHD	APC,CDC20,FZR1	0.8444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons