DegronMD - Q3B820(FAM161A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R306W	TCGA-75-5126	LUAD	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	TCGA-AP-A051	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	TCGA-AP-A0LG	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	DO23711	LUAD	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	DO41823	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	DO42673	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306W	SIDM01145	Gastric Carcinoma	GDSC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.P429S	TCGA-AC-A23H	BRCA	TCGA	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.6752
p.P429S	DO2401	BRCA	ICGC	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.6752
p.P288T	TCGA-AY-6197	COAD	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1944
p.P288T	DO9956	COAD	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1944
p.R307I	TCGA-DF-A2KU	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.0833
p.R307I	DO223286	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.0833
p.K301N	TCGA-EO-A22R	UCEC	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation substituting flanking lysine	0.3611
p.K301N	DO42713	UCEC	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation substituting flanking lysine	0.3611
p.K301R	TCGA-GL-A59R	KIRP	TCGA	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation substituting flanking lysine	0.3611
p.K301R	DO44525	KIRP	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation substituting flanking lysine	0.3611
p.T428A	TCGA-V4-A9EQ	UVM	TCGA	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation altering degron motif	0.825
p.P294L	DO228313	LICA	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation altering degron motif	0.6471
p.V287F	DO228667	LICA	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1667
p.L442I	DO229026	LICA	ICGC	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.0556
p.A284S	DO231047	LUSC	ICGC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.0833
p.L442V	SIDM00643	Non-Cancerous	GDSC	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.0556
p.L442V	ACH-002363	Non-Cancerous	CCLE	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.0556
p.R306Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306Q	ACH-000960	Leukemia	CCLE	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.R306Q	REH	haematopoietic and lymphoid tissue	COSMIC	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.1111
p.K423R	SIDM00333	Endometrial Carcinoma	GDSC	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation substituting flanking lysine	0.3333
p.K423R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation substituting flanking lysine	0.3333
p.K423R	MFE-319	endometrium	COSMIC	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation substituting flanking lysine	0.3333
p.R283Q	ACH-000833	Sarcoma	CCLE	LPLYHD	LIG_APCC_ABBA_1	293:298	Mutation rewiring degron network	0.0556
p.H422Q	ACH-001367	Neuroblastoma	CCLE	PTPDFE	DEG_SCF_FBW7_2	427:432	Mutation rewiring degron network	0.1944

Kaplan plot for FAM161A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM161A

UniProt ID: Q3B820

Entrez ID: 84140

Protein name: Protein FAM161A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM161A in