DegronMD

Uniprot ID: Q3B820

Source protein: Protein FAM161A

Source gene: FAM161A

Class: DEG_SCF_FBW7_2

Location: 427:432

E3 ligase: FBXW7

DEGRON score: 0.7165

ASA_SCORE: 81.5667

COIL: 0.7308

CONS_SCORE: 0.5616

DSS_SCORE: 0.24

HELIX: 0.2565

FCONS_SCORE: 1.1343

RIG_SCORE: 0.7373

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P429S	TCGA-AC-A23H	BRCA	TCGA	PTPDFE	DEG_SCF_FBW7_2	0.6752
p.P429S	DO2401	BRCA	ICGC	PTPDFE	DEG_SCF_FBW7_2	0.6752
p.T428A	TCGA-V4-A9EQ	UVM	TCGA	PTPDFE	DEG_SCF_FBW7_2	0.825
p.L442I	DO229026	LICA	ICGC	PTPDFE	DEG_SCF_FBW7_2	0.0556
p.L442V	SIDM00643	Non-Cancerous	GDSC	PTPDFE	DEG_SCF_FBW7_2	0.0556
p.L442V	ACH-002363	Non-Cancerous	CCLE	PTPDFE	DEG_SCF_FBW7_2	0.0556
p.K423R	SIDM00333	Endometrial Carcinoma	GDSC	PTPDFE	DEG_SCF_FBW7_2	0.3333
p.K423R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PTPDFE	DEG_SCF_FBW7_2	0.3333
p.K423R	MFE-319	endometrium	COSMIC	PTPDFE	DEG_SCF_FBW7_2	0.3333
p.H422Q	ACH-001367	Neuroblastoma	CCLE	PTPDFE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3B820	Protein FAM161A	DEG_SCF_FBW7_2	427:432	PTPDFE	FBXW7	0.7165	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons