DegronMD

Uniprot ID: O75096

Source protein: Low-density lipoprotein receptor-related protein 4

Source gene: LRP4

Class: DEG_SCF_FBW7_1

Location: 1671:1678

E3 ligase: FBXW7

DEGRON score: 0.9659

ASA_SCORE: 76.925

COIL: 0.9018

CONS_SCORE: 0.3377

DSS_SCORE: 0.6505

HELIX: 0.0463

FCONS_SCORE: 1.0147

RIG_SCORE: 0.6496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N1673S	TCGA-C8-A12P	BRCA	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	0.5958
p.N1673S	DO4000	BRCA	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	0.5958
p.S1681Y	TCGA-D1-A17Q	UCEC	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	0.25
p.S1681Y	DO41903	UCEC	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	0.25
p.R1685W	TCGA-DA-A960	SKCM	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	0.1389
p.R1685W	DO219482	SKCM	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	0.1389
p.R1687H	TCGA-EO-A3B0	UCEC	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	0.0833
p.R1687H	DO219773	UCEC	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	0.0833
p.T1688M	DO52658	MALY	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	0.0556
p.A1661D	SIDM00434	Plasma Cell Myeloma	GDSC	LPNTPPTT	DEG_SCF_FBW7_1	0.0556
p.T1662I	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LPNTPPTT	DEG_SCF_FBW7_1	0.0833
p.T1662I	ACH-000869	Lung Cancer	CCLE	LPNTPPTT	DEG_SCF_FBW7_1	0.0833
p.T1662I	NCI-H1568	lung	COSMIC	LPNTPPTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75096	Low-density lipoprotein receptor-related protein 4	DEG_SCF_FBW7_1	1671:1678	LPNTPPTT	FBXW7	0.9659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons