DegronMD - O75096(LRP4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1304P	TCGA-86-8076	LUAD	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1389
p.R1304P	DO24120	LUAD	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1389
p.G1283D	TCGA-AP-A1DK	UCEC	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1667
p.G1283D	DO42033	UCEC	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1667
p.N1673S	TCGA-C8-A12P	BRCA	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation altering degron motif	0.5958
p.N1673S	DO4000	BRCA	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation altering degron motif	0.5958
p.S1681Y	TCGA-D1-A17Q	UCEC	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.25
p.S1681Y	DO41903	UCEC	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.25
p.R1685W	TCGA-DA-A960	SKCM	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.1389
p.R1685W	DO219482	SKCM	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.1389
p.D1303H	TCGA-E2-A1LG	BRCA	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1667
p.D1303H	DO4018	BRCA	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1667
p.G1281S	TCGA-EB-A430	SKCM	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1111
p.G1281S	DO37906	SKCM	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.1111
p.R1687H	TCGA-EO-A3B0	UCEC	TCGA	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0833
p.R1687H	DO219773	UCEC	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0833
p.M1297I	TCGA-FV-A23B	LIHC	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation altering degron motif	0.6507
p.M1297I	DO44872	LIHC	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation altering degron motif	0.6507
p.N1292H	TCGA-HC-A4ZV	PRAD	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation altering degron motif	0.6312
p.N1292H	DO46812	PRAD	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation altering degron motif	0.6312
p.D1279N	TCGA-VS-A958	CESC	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.0556
p.D1279N	DO51639	CESC	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation rewiring degron network	0.0556
p.P1294S	DO230311	COCA	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation altering degron motif	0.5641
p.P1294Q	DO229026	LICA	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	1289:1297	Mutation altering degron motif	0.5924
p.T1688M	DO52658	MALY	ICGC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0556
p.A1661D	SIDM00434	Plasma Cell Myeloma	GDSC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0556
p.T1662I	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0833
p.T1662I	ACH-000869	Lung Cancer	CCLE	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0833
p.T1662I	NCI-H1568	lung	COSMIC	LPNTPPTT	DEG_SCF_FBW7_1	1671:1678	Mutation rewiring degron network	0.0833

Kaplan plot for LRP4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP4

UniProt ID: O75096

Entrez ID: 4038

Protein name: Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LRP4 in