DegronMD

Uniprot ID: O75096

Source protein: Low-density lipoprotein receptor-related protein 4

Source gene: LRP4

Class: DEG_APCC_DBOX_1

Location: 1289:1297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7735

ASA_SCORE: 52.9556

COIL: 0.6582

CONS_SCORE: 0.5946

DSS_SCORE: 0.2888

HELIX: 0.0263

FCONS_SCORE: 1.2233

RIG_SCORE: 0.7928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1304P	TCGA-86-8076	LUAD	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.1389
p.R1304P	DO24120	LUAD	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.1389
p.G1283D	TCGA-AP-A1DK	UCEC	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.1667
p.G1283D	DO42033	UCEC	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.1667
p.D1303H	TCGA-E2-A1LG	BRCA	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.1667
p.D1303H	DO4018	BRCA	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.1667
p.G1281S	TCGA-EB-A430	SKCM	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.1111
p.G1281S	DO37906	SKCM	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.1111
p.M1297I	TCGA-FV-A23B	LIHC	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.6507
p.M1297I	DO44872	LIHC	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.6507
p.N1292H	TCGA-HC-A4ZV	PRAD	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.6312
p.N1292H	DO46812	PRAD	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.6312
p.D1279N	TCGA-VS-A958	CESC	TCGA	VRSNLPGLM	DEG_APCC_DBOX_1	0.0556
p.D1279N	DO51639	CESC	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.0556
p.P1294S	DO230311	COCA	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.5641
p.P1294Q	DO229026	LICA	ICGC	VRSNLPGLM	DEG_APCC_DBOX_1	0.5924

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75096	Low-density lipoprotein receptor-related protein 4	DEG_APCC_DBOX_1	1289:1297	VRSNLPGLM	APC,CDC20,FZR1	0.7735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons