DegronMD

Uniprot ID: Q9UIG8

Source protein: Solute carrier organic anion transporter family member 3A1

Source gene: SLCO3A1

Class: LIG_APCC_ABBA_1

Location: 289:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.549

ASA_SCORE: 84.3167

COIL: 0.9123

CONS_SCORE: 0.4412

DSS_SCORE: 0.4291

HELIX: 0.0615

FCONS_SCORE: 0.9405

RIG_SCORE: 0.6387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M297I	TCGA-04-1652	OV	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.25
p.M297I	DO29248	OV	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.25
p.F283C	TCGA-44-7671	LUAD	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.1667
p.F283C	DO25252	LUAD	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.1667
p.A302P	TCGA-85-7698	LUSC	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.1111
p.A302P	DO27723	LUSC	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.1111
p.P286S	TCGA-DU-6392	LGG	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.25
p.P286S	DO22237	LGG	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.25
p.S279C	TCGA-FW-A3R5	SKCM	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.0556
p.S279C	DO37406	SKCM	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.0556
p.L280F	TCGA-FW-A3R5	SKCM	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.0833
p.L280F	DO37406	SKCM	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.0833
p.A296T	TCGA-G4-6586	COAD	TCGA	LPPHSE	LIG_APCC_ABBA_1	0.2778
p.A296T	DO9698	COAD	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.2778
p.A296T	SIDM00853	Other Sarcomas	GDSC	LPPHSE	LIG_APCC_ABBA_1	0.2778
p.A296T	GCT	soft_tissue	COSMIC	LPPHSE	LIG_APCC_ABBA_1	0.2778
p.E294D	DO229010	COCA	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.5647
p.E294D	DO229013	COCA	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.5647
p.E294D	DO229016	COCA	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.5647
p.E294D	DO229003	COCA	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.5647
p.E294D	DO229005	COCA	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.5647
p.P291T	DO219966	SARC	ICGC	LPPHSE	LIG_APCC_ABBA_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UIG8	Solute carrier organic anion transporter family member 3A1	LIG_APCC_ABBA_1	289:294	LPPHSE	APC,CDC20,FZR1	0.549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons