DegronMD

Uniprot ID: Q9UKV0

Source protein: Histone deacetylase 9

Source gene: HDAC9

Class: DEG_SCF_FBW7_2

Location: 294:301

E3 ligase: FBXW7

DEGRON score: 0.9

ASA_SCORE: 84.825

COIL: 0.8033

CONS_SCORE: 0.3233

DSS_SCORE: 0.6601

HELIX: 0.1663

FCONS_SCORE: 0.9963

RIG_SCORE: 0.6764

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V307F	TCGA-17-Z022	LUAD	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.1667
p.M306I	TCGA-66-2759	LUSC	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.1944
p.V307D	TCGA-C9-A47Z	HNSC	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.1667
p.R311H	TCGA-E6-A1LX	UCEC	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.0556
p.R311H	SIDM00527	Colorectal Carcinoma	GDSC	LPPTPHAE	DEG_SCF_FBW7_2	0.0556
p.R311H	MDST8	large_intestine	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.0556
p.A303V	TCGA-FS-A1ZW	SKCM	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.2778
p.S295L	TCGA-FW-A3R5	SKCM	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.7667
p.S295P	TCGA-L5-A43J	ESCA	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.6752
p.P298S	TCGA-L5-A88V	ESCA	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.6752
p.T300I	TCGA-LN-A4A3	ESCA	TCGA	LPPTPHAE	DEG_SCF_FBW7_2	0.7078
p.L290M	DO8634	COAD	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.2222
p.L304V	DO222760	COCA	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.25
p.P307L	DO50374	ESAD	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.1667
p.P300L	DO233621	GACA	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.7582
p.S298F	DO228983	LICA	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.7982
p.D286Y	DO26444	LUSC	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.1111
p.P300S	DO37623	SKCM	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.6752
p.G305V	DO47374	SKCM	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.2222
p.M288I	DO41235	UCEC	ICGC	LPPTPHAE	DEG_SCF_FBW7_2	0.1667
p.V289F	SIDM00231	Kidney Carcinoma	GDSC	LPPTPHAE	DEG_SCF_FBW7_2	0.1944
p.V289F	NCC010	kidney	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1944
p.E304K	SIDM00251	Gastric Carcinoma	GDSC	LPPTPHAE	DEG_SCF_FBW7_2	0.25
p.P301R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	LPPTPHAE	DEG_SCF_FBW7_2	0.7512
p.P301R	NCI-H1568	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.7512
p.H301Q	ACH-000335	Lung Cancer	CCLE	LPPTPHAE	DEG_SCF_FBW7_2	0.7582
p.H301Q	MSTO-211H	pleura	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.7582
p.G289V	ACH-000463	Lung Cancer	CCLE	LPPTPHAE	DEG_SCF_FBW7_2	0.1944
p.G289V	NCI-H460	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1944
p.V286F	NCC010	kidney	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1111
p.P298R	NCI-H1568	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.7512
p.S285Y	SNU-81	large_intestine	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.0833
p.R306H	MDST8	large_intestine	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1944
p.R308H	MDST8	large_intestine	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1389
p.L297I	NCI-H1666	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.7174
p.P296R	NCI-H1568	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.6401
p.S298Y	SNU-81	large_intestine	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.712
p.V284F	NCC010	kidney	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.0556
p.E308Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1389
p.L310I	NCI-H1666	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.0833
p.E305Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.2222
p.P285R	NCI-H1568	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.0833
p.L308I	NCI-H1666	lung	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.1389
p.R295H	MDST8	large_intestine	COSMIC	LPPTPHAE	DEG_SCF_FBW7_2	0.8244

Drug responses associated with HDAC9 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000404	Skin Cancer	p.P15S (No)	CCLE	Panobinostat	0.0451
ACH-000404	Skin Cancer	p.P15S (No)	CCLE	Sorafenib	8
ACH-000638	Lung Cancer	p.P23T (No)	CCLE	Panobinostat	0.1213
ACH-000638	Lung Cancer	p.P23T (No)	CCLE	Sorafenib	8
ACH-000945	Lung Cancer	p.M34I (No)	CCLE	Panobinostat	0.1457
ACH-000945	Lung Cancer	p.M34I (No)	CCLE	Sorafenib	8
ACH-000974	Endometrial/Uterine Cancer	p.R119H (No)	CCLE	Panobinostat	0.1365
ACH-000974	Endometrial/Uterine Cancer	p.R119H (No)	CCLE	Sorafenib	8
ACH-000564	Myeloma	p.R136S (No)	CCLE	Panobinostat	0.0189
ACH-000564	Myeloma	p.R136S (No)	CCLE	Sorafenib	4.0152
ACH-000985	Colon/Colorectal Cancer	p.R171H (No)	CCLE	Panobinostat	0.0359
ACH-000985	Colon/Colorectal Cancer	p.R171H (No)	CCLE	Sorafenib	8
ACH-000899	Skin Cancer	p.P142S (No)	CCLE	Panobinostat	0.0953
ACH-000899	Skin Cancer	p.P142S (No)	CCLE	Sorafenib	8
ACH-000019	Breast Cancer	p.H182R (No)	CCLE	Sorafenib	8
ACH-000869	Lung Cancer	p.P221R (No)	CCLE	Panobinostat	0.0588
ACH-000869	Lung Cancer	p.P221R (No)	CCLE	Sorafenib	7.9219
ACH-000448	Lung Cancer	p.L310I (Yes)	CCLE	Panobinostat	0.0699
ACH-000448	Lung Cancer	p.L310I (Yes)	CCLE	Sorafenib	8
ACH-000463	Lung Cancer	p.G366V (No)	CCLE	Panobinostat	0.0987
ACH-000463	Lung Cancer	p.G366V (No)	CCLE	Sorafenib	8
ACH-000335	Lung Cancer	p.H378Q (No)	CCLE	Panobinostat	0.0737
ACH-000335	Lung Cancer	p.H378Q (No)	CCLE	Sorafenib	6.9818
ACH-000848	Liver Cancer	p.G415A (No)	CCLE	Panobinostat	0.0567
ACH-000848	Liver Cancer	p.G415A (No)	CCLE	Sorafenib	4.189
ACH-000988	Endometrial/Uterine Cancer	p.R429K (No)	CCLE	Panobinostat	0.0597
ACH-000988	Endometrial/Uterine Cancer	p.R429K (No)	CCLE	Sorafenib	8
ACH-000361	Liver Cancer	p.G433D (No)	CCLE	Panobinostat	0.041
ACH-000361	Liver Cancer	p.G433D (No)	CCLE	Sorafenib	8
ACH-000813	Lung Cancer	p.G356V (No)	CCLE	Panobinostat	0.0737
ACH-000813	Lung Cancer	p.G356V (No)	CCLE	Sorafenib	8
ACH-000643	Breast Cancer	p.R442C (No)	CCLE	Panobinostat	0.0426
ACH-000643	Breast Cancer	p.R442C (No)	CCLE	Sorafenib	8
ACH-000667	Lung Cancer	p.Q475K (No)	CCLE	Panobinostat	0.0689
ACH-000667	Lung Cancer	p.Q475K (No)	CCLE	Sorafenib	8
ACH-000971	Colon/Colorectal Cancer	p.Q510fs (No)	CCLE	Panobinostat	0.0404
ACH-000971	Colon/Colorectal Cancer	p.Q510fs (No)	CCLE	Sorafenib	6.2089
ACH-000766	Lung Cancer	p.G511W (No)	CCLE	Panobinostat	0.0861
ACH-000766	Lung Cancer	p.G511W (No)	CCLE	Sorafenib	8
ACH-000912	Lung Cancer	p.G434V (No)	CCLE	Panobinostat	0.0415
ACH-000912	Lung Cancer	p.G434V (No)	CCLE	Sorafenib	7.0014
ACH-000888	Lung Cancer	p.T527A (No)	CCLE	Sorafenib	8
ACH-000845	Lung Cancer	p.R451M (No)	CCLE	Panobinostat	0.1081
ACH-000845	Lung Cancer	p.R451M (No)	CCLE	Sorafenib	8
ACH-000980	Lung Cancer	p.A614V (No)	CCLE	Panobinostat	0.0455
ACH-000980	Lung Cancer	p.A614V (No)	CCLE	Sorafenib	8
ACH-000962	Ovarian Cancer	p.R670Q (No)	CCLE	Panobinostat	0.138
ACH-000962	Ovarian Cancer	p.R670Q (No)	CCLE	Sorafenib	8
ACH-001145	Ovarian Cancer	p.R670Q (No)	CCLE	Panobinostat	0.12
ACH-001145	Ovarian Cancer	p.R670Q (No)	CCLE	Sorafenib	8
ACH-000065	Leukemia	p.N705S (No)	CCLE	Panobinostat	0.0114
ACH-000065	Leukemia	p.N705S (No)	CCLE	Sorafenib	1.3256
ACH-000053	Lymphoma	p.G709R (No)	CCLE	Panobinostat	0.0623
ACH-000053	Lymphoma	p.G709R (No)	CCLE	Sorafenib	8
ACH-000627	Lung Cancer	p.D739V (No)	CCLE	Panobinostat	0.1041
ACH-000627	Lung Cancer	p.D739V (No)	CCLE	Sorafenib	8
ACH-000879	Endometrial/Uterine Cancer	p.R752H (No)	CCLE	Panobinostat	0.0605
ACH-000879	Endometrial/Uterine Cancer	p.R752H (No)	CCLE	Sorafenib	8
ACH-000811	Ovarian Cancer	p.C757S (No)	CCLE	Panobinostat	0.1414
ACH-000811	Ovarian Cancer	p.C757S (No)	CCLE	Sorafenib	8
ACH-000847	Gastric Cancer	p.D820H (No)	CCLE	Panobinostat	0.0389
ACH-000847	Gastric Cancer	p.D820H (No)	CCLE	Sorafenib	8
ACH-000987	Skin Cancer	p.G867E (No)	CCLE	Panobinostat	0.1065
ACH-000987	Skin Cancer	p.G867E (No)	CCLE	Sorafenib	8
ACH-000322	Skin Cancer	p.G886E (No)	CCLE	Panobinostat	0.088
ACH-000322	Skin Cancer	p.G886E (No)	CCLE	Sorafenib	8
ACH-000966	Ovarian Cancer	p.A915V (No)	CCLE	Panobinostat	0.0954
ACH-000966	Ovarian Cancer	p.A915V (No)	CCLE	Sorafenib	6.6023
ACH-001233	Lung Cancer	p.H956N (No)	CCLE	Panobinostat	0.0081
ACH-001233	Lung Cancer	p.H956N (No)	CCLE	Sorafenib	8
ACH-000900	Lung Cancer	p.G974* (No)	CCLE	Panobinostat	0.0654
ACH-000900	Lung Cancer	p.G974* (No)	CCLE	Sorafenib	8
ACH-000781	Lung Cancer	p.Q987L (No)	CCLE	Panobinostat	0.0933
ACH-000781	Lung Cancer	p.Q987L (No)	CCLE	Sorafenib	8
ACH-000745	Myeloma	p.L1030F (No)	CCLE	Panobinostat	0.018
ACH-000745	Myeloma	p.L1030F (No)	CCLE	Sorafenib	8
ACH-000899	Skin Cancer	p.V1037I (No)	CCLE	Panobinostat	0.0953
ACH-000899	Skin Cancer	p.V1037I (No)	CCLE	Sorafenib	8
ACH-000878	Lung Cancer	p.T1044K (No)	CCLE	Panobinostat	0.0431
ACH-000878	Lung Cancer	p.T1044K (No)	CCLE	Sorafenib	8
ACH-001318	Liver Cancer	p.A1052S (No)	CCLE	Panobinostat	0.0373
ACH-001318	Liver Cancer	p.A1052S (No)	CCLE	Sorafenib	8
ACH-000580	Skin Cancer	p.G1060C (No)	CCLE	Panobinostat	0.5973
ACH-000580	Skin Cancer	p.G1060C (No)	CCLE	Sorafenib	8
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	VNLG/124	8.7182
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	Trichostatin A	0.0873
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R670* (No)	GDSC	Panobinostat	0.0083
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R260* (No)	GDSC	Trichostatin A	0.0167
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R260* (No)	GDSC	Panobinostat	0.0024
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	VNLG/124	46.9735
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	Trichostatin A	0.0429
SIDM00783	COREAD\|large_intestine	p.D515fs*34 (No)	GDSC	Panobinostat	0.0095
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.G958* (No)	GDSC	Panobinostat	0.0334
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	VNLG/124	46.8364
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	Trichostatin A	0.2766
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.D742V (No)	GDSC	Panobinostat	0.058
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	VNLG/124	39.4529
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	Trichostatin A	0.2071
SIDM01164	LGG\|glioma	p.T583M (No)	GDSC	Panobinostat	0.0604
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	VNLG/124	34.5964
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	Trichostatin A	0.1391
SIDM01029	ESCA\|oesophagus	p.A625V (No)	GDSC	Panobinostat	0.155
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	VNLG/124	38.6195
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	Trichostatin A	0.1967
SIDM00614	LIHC\|liver	p.G418A (No)	GDSC	Panobinostat	0.043
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	VNLG/124	16.6724
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	Trichostatin A	0.0608
SIDM00688	DLBC\|B_cell_lymphoma	p.A967T (No)	GDSC	Panobinostat	0.0037
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	VNLG/124	7.6646
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	Trichostatin A	0.0856
SIDM00145	ALL\|lymphoblastic_leukemia	p.E352Q (No)	GDSC	Panobinostat	0.0066
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	VNLG/124	7.6646
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	Trichostatin A	0.0856
SIDM00145	ALL\|lymphoblastic_leukemia	p.P624L (No)	GDSC	Panobinostat	0.0066
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	VNLG/124	10.2625
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	Trichostatin A	0.2111
SIDM00227	NB\|neuroblastoma	p.S730F (No)	GDSC	Panobinostat	0.0317
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	VNLG/124	33.0648
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	Trichostatin A	0.3686
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.Q114H (No)	GDSC	Panobinostat	0.029
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (No)	GDSC	VNLG/124	8.7182
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (No)	GDSC	Trichostatin A	0.0873
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.P376L (No)	GDSC	Panobinostat	0.0083
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	VNLG/124	58.0382
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	Trichostatin A	0.143
SIDM00683	PRAD\|prostate	p.G167A (No)	GDSC	Panobinostat	0.0482
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	VNLG/124	85.9408
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	Trichostatin A	0.1374
SIDM00334	UCEC\|endometrium	p.R755H (No)	GDSC	Panobinostat	0.0642
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	VNLG/124	54.201
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	Trichostatin A	0.226
SIDM00138	LUAD\|lung_NSCLC_adenocarcinoma	p.G977* (No)	GDSC	Panobinostat	0.0496
SIDM00527	COREAD\|large_intestine	p.R311H (Yes)	GDSC	VNLG/124	61.6904
SIDM00527	COREAD\|large_intestine	p.R311H (Yes)	GDSC	Trichostatin A	0.2879
SIDM00527	COREAD\|large_intestine	p.R311H (Yes)	GDSC	Panobinostat	0.025
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	VNLG/124	41.2658
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	Trichostatin A	0.1661
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A617V (No)	GDSC	Panobinostat	0.0493
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	VNLG/124	18.3585
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	Trichostatin A	0.0166
SIDM01007	ALL\|lymphoblastic_leukemia	p.T181M (No)	GDSC	Panobinostat	0.0023
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	VNLG/124	82.2204
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	Trichostatin A	0.9894
SIDM01093	CESC\|cervix	p.A625V (No)	GDSC	Panobinostat	0.3117
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	VNLG/124	45.1726
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	Trichostatin A	0.3504
SIDM01174	CESC\|cervix	p.S454C (No)	GDSC	Panobinostat	0.1305
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	VNLG/124	45.1726
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	Trichostatin A	0.3504
SIDM01174	CESC\|cervix	p.T940M (No)	GDSC	Panobinostat	0.1305
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	VNLG/124	224.5319
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	Trichostatin A	2.0488
SIDM00755	LUAD\|lung_NSCLC_adenocarcinoma	p.T530A (No)	GDSC	Panobinostat	0.8585
SIDM00126	SKCM\|melanoma	p.P924S (No)	GDSC	VNLG/124	76.4995
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	VNLG/124	132.7935
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	Trichostatin A	0.8621
SIDM00466	OV\|ovary	p.L867V (No)	GDSC	Panobinostat	0.1676
SIDM00251	STAD\|stomach	p.E304K (Yes)	GDSC	VNLG/124	21.9133
SIDM00251	STAD\|stomach	p.E304K (Yes)	GDSC	Trichostatin A	0.1589
SIDM00251	STAD\|stomach	p.E304K (Yes)	GDSC	Panobinostat	0.111
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	VNLG/124	63.0929
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	Trichostatin A	0.1949
SIDM00214	COREAD\|large_intestine	p.V172M (No)	GDSC	Panobinostat	0.0406
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	VNLG/124	46.3341
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	Trichostatin A	0.6267
SIDM00220	OV\|ovary	p.R670Q (No)	GDSC	Panobinostat	0.0518
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	VNLG/124	94.0787
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	Trichostatin A	0.2469
SIDM00498	COREAD\|large_intestine	p.L580M (No)	GDSC	Panobinostat	0.0601
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	VNLG/124	8.888
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	Trichostatin A	0.0755
SIDM00907	UNCLASSIFIED\|Burkitt_lymphoma	p.A859D (No)	GDSC	Panobinostat	0.0106
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	VNLG/124	67.0543
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	Trichostatin A	0.7506
SIDM00982	GBM\|glioma	p.A859D (No)	GDSC	Panobinostat	0.0494
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	VNLG/124	43.8004
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	Trichostatin A	0.063
SIDM00434	MM\|myeloma	p.L1030F (No)	GDSC	Panobinostat	0.0079
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.H657Y (No)	GDSC	VNLG/124	16.7018
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.H657Y (No)	GDSC	Trichostatin A	0.0906
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	VNLG/124	26.9059
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	Trichostatin A	0.1294
SIDM00946	ALL\|T_cell_leukemia	p.N813T (No)	GDSC	Panobinostat	0.0165
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	VNLG/124	23.0783
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	Trichostatin A	0.1961
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q111L (No)	GDSC	Panobinostat	0.0139
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	VNLG/124	38.0701
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	Trichostatin A	0.0681
SIDM00333	UCEC\|endometrium	p.R432K (No)	GDSC	Panobinostat	0.029
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	VNLG/124	69.5809
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	Trichostatin A	0.4566
SIDM00794	UNCLASSIFIED\|skin_other	p.A859D (No)	GDSC	Panobinostat	0.2065
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	VNLG/124	69.5809
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	Trichostatin A	0.4566
SIDM00794	UNCLASSIFIED\|skin_other	p.H868Y (No)	GDSC	Panobinostat	0.2065
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	VNLG/124	19.5974
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	Trichostatin A	0.0572
SIDM00600	THCA\|thyroid	p.T791K (No)	GDSC	Panobinostat	0.021
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	VNLG/124	22.6152
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	Trichostatin A	0.0798
SIDM00507	UNCLASSIFIED\|lung_other	p.R445H (No)	GDSC	Panobinostat	0.008
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	VNLG/124	42.2889
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	Trichostatin A	0.1885
SIDM00217	COREAD\|large_intestine	p.A1041T (No)	GDSC	Panobinostat	0.0494
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	VNLG/124	12.6789
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	Trichostatin A	0.402
SIDM01069	LUAD\|lung_NSCLC_adenocarcinoma	p.Q478K (No)	GDSC	Panobinostat	0.0672
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	VNLG/124	68.3252
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	Trichostatin A	0.1939
SIDM00681	COREAD\|large_intestine	p.V609I (No)	GDSC	Panobinostat	0.0959
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	VNLG/124	59.6889
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	Trichostatin A	0.2542
SIDM00839	COREAD\|large_intestine	p.P616S (No)	GDSC	Panobinostat	0.0291
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	VNLG/124	140.7267
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	Trichostatin A	24.6674
SIDM00282	COREAD\|large_intestine	p.S3I (No)	GDSC	Panobinostat	26.5314
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	VNLG/124	140.7267
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	Trichostatin A	24.6674
SIDM00282	COREAD\|large_intestine	p.S394T (No)	GDSC	Panobinostat	26.5314
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	VNLG/124	66.551
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	Trichostatin A	0.5086
SIDM00102	MESO\|mesothelioma	p.I5M (No)	GDSC	Panobinostat	0.1247
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	VNLG/124	66.551
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	Trichostatin A	0.5086
SIDM00102	MESO\|mesothelioma	p.T1058I (No)	GDSC	Panobinostat	0.1247
SIDM00640	MESO\|mesothelioma	p.H381Q (No)	GDSC	VNLG/124	41.3922
SIDM00640	MESO\|mesothelioma	p.H381Q (No)	GDSC	Trichostatin A	0.3737
SIDM00640	MESO\|mesothelioma	p.H381Q (No)	GDSC	Panobinostat	0.1272
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	VNLG/124	50.1704
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	Trichostatin A	0.0489
SIDM00660	COREAD\|large_intestine	p.R174H (No)	GDSC	Panobinostat	0.0104
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	VNLG/124	74.7738
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	Trichostatin A	0.2465
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.T160S (No)	GDSC	Panobinostat	0.0604
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.A142T (No)	GDSC	VNLG/124	28.523
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	VNLG/124	46.9735
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	Trichostatin A	0.0429
SIDM00783	COREAD\|large_intestine	p.R141G (No)	GDSC	Panobinostat	0.0095
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	VNLG/124	142.837
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	Trichostatin A	0.2496
SIDM00925	LUAD\|lung_NSCLC_adenocarcinoma	p.P23T (No)	GDSC	Panobinostat	0.0667
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	VNLG/124	4.9582
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	Trichostatin A	0.0887
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V758A (No)	GDSC	Panobinostat	0.0171
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	VNLG/124	91.025
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	Trichostatin A	0.2171
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G735R (No)	GDSC	Panobinostat	0.0472
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.V253L (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.D539E (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S568C (No)	GDSC	Panobinostat	0.1073
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	VNLG/124	48.0354
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	Trichostatin A	0.697
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.S874A (No)	GDSC	Panobinostat	0.1073
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	VNLG/124	91.0538
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	Trichostatin A	0.971
SIDM00753	LUAD\|lung_NSCLC_adenocarcinoma	p.Q990L (No)	GDSC	Panobinostat	0.0967
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	VNLG/124	107.9185
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	Trichostatin A	0.1623
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.L313I (No)	GDSC	Panobinostat	0.0685
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	VNLG/124	79.1092
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	Trichostatin A	0.1509
SIDM00143	SCLC\|lung_small_cell_carcinoma	p.G752C (No)	GDSC	Panobinostat	0.2047
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.K161N (No)	GDSC	Panobinostat	0.0334
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	VNLG/124	46.4268
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	Trichostatin A	0.0844
SIDM00534	COREAD\|large_intestine	p.R682* (No)	GDSC	Panobinostat	0.0334
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	VNLG/124	104.0033
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	Trichostatin A	0.2261
SIDM00207	GBM\|glioma	p.Q472E (No)	GDSC	Panobinostat	0.1004
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	VNLG/124	56.1435
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	Trichostatin A	0.3061
SIDM00336	SKCM\|melanoma	p.R122C (No)	GDSC	Panobinostat	0.0618
SIDM00585	LIHC\|liver	p.M261I (No)	GDSC	VNLG/124	76.4064
SIDM00585	LIHC\|liver	p.M261I (No)	GDSC	Trichostatin A	1.1925
SIDM00585	LIHC\|liver	p.M261I (No)	GDSC	Panobinostat	1.0336
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	VNLG/124	77.3108
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	Trichostatin A	0.6175
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.R139M (No)	GDSC	Panobinostat	0.0997
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	VNLG/124	77.3108
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	Trichostatin A	0.6175
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.N252I (No)	GDSC	Panobinostat	0.0997
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	VNLG/124	21.5926
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	Trichostatin A	0.0698
SIDM00290	STAD\|stomach	p.D823H (No)	GDSC	Panobinostat	0.0235
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	VNLG/124	22.0655
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	Trichostatin A	0.4753
SIDM01110	LIHC\|liver	p.G436D (No)	GDSC	Panobinostat	0.0806
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	VNLG/124	68.4196
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	Trichostatin A	0.0415
SIDM00548	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R611S (No)	GDSC	Panobinostat	0.0151
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G1027R (No)	GDSC	Trichostatin A	0.0487
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.G1027R (No)	GDSC	Panobinostat	0.017
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (No)	GDSC	VNLG/124	54.6187
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (No)	GDSC	Trichostatin A	0.2516
SIDM00144	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G369V (No)	GDSC	Panobinostat	0.0764
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (Yes)	GDSC	VNLG/124	75.2076
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (Yes)	GDSC	Trichostatin A	10.7702
SIDM00750	LUAD\|lung_NSCLC_adenocarcinoma	p.P301R (Yes)	GDSC	Panobinostat	0.5964
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	VNLG/124	91.0599
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	Trichostatin A	0.2467
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.T1044K (No)	GDSC	Panobinostat	0.156
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	VNLG/124	61.3947
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	Trichostatin A	0.4604
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.P884H (No)	GDSC	Panobinostat	0.299
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	VNLG/124	195.3063
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	Trichostatin A	1.3676
SIDM00890	SKCM\|melanoma	p.G1060C (No)	GDSC	Panobinostat	0.5473
SIDM00383	UNCLASSIFIED\|stomach	p.A625V (No)	GDSC	VNLG/124	45.1114
SIDM00383	UNCLASSIFIED\|stomach	p.A625V (No)	GDSC	Trichostatin A	0.0528
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	VNLG/124	121.3447
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	Trichostatin A	0.38
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.M34I (No)	GDSC	Panobinostat	0.0399
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	VNLG/124	34.5057
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	Trichostatin A	0.2205
SIDM00746	LUAD\|lung_NSCLC_adenocarcinoma	p.G514W (No)	GDSC	Panobinostat	0.2424
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	VNLG/124	53.5821
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	Trichostatin A	0.021
SIDM00148	BRCA\|breast	p.H185R (No)	GDSC	Panobinostat	0.0261
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	VNLG/124	20.4972
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	Trichostatin A	0.1897
SIDM01027	ESCA\|oesophagus	p.A778P (No)	GDSC	Panobinostat	0.0684
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	VNLG/124	91.525
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	Trichostatin A	0.3886
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.D627E (No)	GDSC	Panobinostat	0.0311
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	VNLG/124	43.7393
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	Trichostatin A	0.7903
SIDM01062	BRCA\|breast	p.R445C (No)	GDSC	Panobinostat	0.3669
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	VNLG/124	28.4171
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	Trichostatin A	0.374
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.V118L (No)	GDSC	Panobinostat	0.0678
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	VNLG/124	84.9584
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	Trichostatin A	1.0881
SIDM00734	LUAD\|lung_NSCLC_adenocarcinoma	p.S532R (No)	GDSC	Panobinostat	0.0976
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	VNLG/124	44.3849
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	Trichostatin A	0.1199
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.G712R (No)	GDSC	Panobinostat	0.0176
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	VNLG/124	132.1749
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	Trichostatin A	0.3336
SIDM00193	COREAD\|large_intestine	p.S329Y (No)	GDSC	Panobinostat	0.1051
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	VNLG/124	132.1749
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	Trichostatin A	0.3336
SIDM00193	COREAD\|large_intestine	p.S1007Y (No)	GDSC	Panobinostat	0.1051
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	VNLG/124	50.3006
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	Trichostatin A	0.172
SIDM00118	COREAD\|large_intestine	p.R409Q (No)	GDSC	Panobinostat	0.0443

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPPTPHAE

Degron related mutations and impact score

Drug responses associated with HDAC9 mutations

All proteins holding degron of LPPTPHAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKV0	Histone deacetylase 9	DEG_SCF_FBW7_2	294:301	LPPTPHAE	FBXW7	0.9	More...