DegronMD

Uniprot ID: Q8WXD9

Source protein: Caskin-1

Source gene: CASKIN1

Class: DEG_SCF_FBW7_1

Location: 682:689

E3 ligase: FBXW7

DEGRON score: 0.8006

ASA_SCORE: 96.85

COIL: 0.9598

CONS_SCORE: 0.3564

DSS_SCORE: 0.8761

HELIX: 0.0191

FCONS_SCORE: 1.0513

RIG_SCORE: 0.5985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R699L	TCGA-55-7281	LUAD	TCGA	LPPTPRAT	DEG_SCF_FBW7_1	0.0556
p.R699L	TCGA-CV-7261	HNSC	TCGA	LPPTPRAT	DEG_SCF_FBW7_1	0.0556
p.R699L	DO15062	HNSC	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	0.0556
p.R699L	DO25985	LUAD	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	0.0556
p.G698C	TCGA-GN-A26C	SKCM	TCGA	LPPTPRAT	DEG_SCF_FBW7_1	0.0833
p.G698C	DO37782	SKCM	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	0.0833
p.H681N	DO33091	PACA	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	0.3056
p.Q692H	DO232224	PBCA	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	0.25
p.R691Q	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	0.2778
p.R691Q	SIDM01587	Bladder Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	0.2778
p.D693N	SIDM00068	Colorectal Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	0.2222
p.D693N	ACH-002394	Colon/Colorectal Cancer	CCLE	LPPTPRAT	DEG_SCF_FBW7_1	0.2222
p.D693N	GEO	large_intestine	COSMIC	LPPTPRAT	DEG_SCF_FBW7_1	0.2222
p.P684S	SIDM00056	Thyroid Gland Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	0.5641
p.P684S	ACH-002148	Thyroid Cancer	CCLE	LPPTPRAT	DEG_SCF_FBW7_1	0.5641
p.P684S	K5	thyroid	COSMIC	LPPTPRAT	DEG_SCF_FBW7_1	0.5641
p.G697R	ACH-000678	Gastric Cancer	CCLE	LPPTPRAT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXD9	Caskin-1	DEG_SCF_FBW7_1	682:689	LPPTPRAT	FBXW7	0.8006	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons