DegronMD - Q8WXD9(CASKIN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G792W	TCGA-05-4396	LUAD	TCGA	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.0833
p.G792W	DO23838	LUAD	ICGC	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.0833
p.R699L	TCGA-55-7281	LUAD	TCGA	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.0556
p.R699L	TCGA-CV-7261	HNSC	TCGA	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.0556
p.R699L	DO15062	HNSC	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.0556
p.R699L	DO25985	LUAD	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.0556
p.L791F	TCGA-EB-A5UN	SKCM	TCGA	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1111
p.L791F	DO47267	SKCM	ICGC	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1111
p.G698C	TCGA-GN-A26C	SKCM	TCGA	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.0833
p.G698C	DO37782	SKCM	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.0833
p.K782E	DO225214	BRCA	ICGC	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation altering degron motif	0.591
p.L729M	DO234320	ESAD	ICGC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation rewiring degron network	0.1667
p.S750N	DO229039	LICA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation rewiring degron network	0.0833
p.E741K	DO222542	MELA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation altering degron motif	0.7022
p.H681N	DO33091	PACA	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.3056
p.Q692H	DO232224	PBCA	ICGC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.25
p.T737P	DO219881	SKCA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation altering degron motif	0.8142
p.T737P	DO218908	SKCA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation altering degron motif	0.8142
p.R740G	DO219881	SKCA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation altering degron motif	0.6457
p.P738L	SIDM00078	Oral Cavity Carcinoma	GDSC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation altering degron motif	0.7582
p.R784Q	SIDM00454	Rhabdomyosarcoma	GDSC	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.3056
p.R691Q	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.2778
p.R691Q	SIDM01587	Bladder Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.2778
p.E731D	SIDM00251	Gastric Carcinoma	GDSC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation rewiring degron network	0.2222
p.E731D	ACH-000949	Gastric Cancer	CCLE	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation rewiring degron network	0.2222
p.D693N	SIDM00068	Colorectal Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.2222
p.D693N	ACH-002394	Colon/Colorectal Cancer	CCLE	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.2222
p.D693N	GEO	large intestine	COSMIC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.2222
p.G748S	SIDM00996	Thyroid Gland Carcinoma	GDSC	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation rewiring degron network	0.1389
p.P684S	SIDM00056	Thyroid Gland Carcinoma	GDSC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation altering degron motif	0.5641
p.P684S	ACH-002148	Thyroid Cancer	CCLE	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation altering degron motif	0.5641
p.P684S	K5	thyroid	COSMIC	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation altering degron motif	0.5641
p.G697R	ACH-000678	Gastric Cancer	CCLE	LPPTPRAT	DEG_SCF_FBW7_1	682:689	Mutation rewiring degron network	0.1111
p.E731K	ACH-000740	Head and Neck Cancer	CCLE	PGTPPRE	DEG_SCF_FBW7_2	735:741	Mutation rewiring degron network	0.2222
p.P788S	ACH-000958	Colon/Colorectal Cancer	CCLE	PPQTPTKT	DEG_SCF_FBW7_1	776:783	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASKIN1

UniProt ID: Q8WXD9

Entrez ID: 57524

Protein name: Caskin-1 (CASK-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASKIN1 in