DegronMD

Uniprot ID: Q8WXD9

Source protein: Caskin-1

Source gene: CASKIN1

Class: DEG_SCF_FBW7_1

Location: 776:783

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 99.3875

COIL: 0.9663

CONS_SCORE: 0.5015

DSS_SCORE: 0.8776

HELIX: 0.0135

FCONS_SCORE: 1.3222

RIG_SCORE: 0.5825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G792W	TCGA-05-4396	LUAD	TCGA	PPQTPTKT	DEG_SCF_FBW7_1	0.0833
p.G792W	DO23838	LUAD	ICGC	PPQTPTKT	DEG_SCF_FBW7_1	0.0833
p.L791F	TCGA-EB-A5UN	SKCM	TCGA	PPQTPTKT	DEG_SCF_FBW7_1	0.1111
p.L791F	DO47267	SKCM	ICGC	PPQTPTKT	DEG_SCF_FBW7_1	0.1111
p.K782E	DO225214	BRCA	ICGC	PPQTPTKT	DEG_SCF_FBW7_1	0.591
p.R784Q	SIDM00454	Rhabdomyosarcoma	GDSC	PPQTPTKT	DEG_SCF_FBW7_1	0.3056
p.P788S	ACH-000958	Colon/Colorectal Cancer	CCLE	PPQTPTKT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXD9	Caskin-1	DEG_SCF_FBW7_1	776:783	PPQTPTKT	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons