DegronMD

Uniprot ID: Q8WXD9

Source protein: Caskin-1

Source gene: CASKIN1

Class: DEG_SCF_FBW7_2

Location: 735:741

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 96.9

COIL: 0.9383

CONS_SCORE: 0.451

DSS_SCORE: 0.8263

HELIX: 0.0293

FCONS_SCORE: 1.2213

RIG_SCORE: 0.5299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L729M	DO234320	ESAD	ICGC	PGTPPRE	DEG_SCF_FBW7_2	0.1667
p.S750N	DO229039	LICA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	0.0833
p.E741K	DO222542	MELA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	0.7022
p.T737P	DO219881	SKCA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	0.8142
p.T737P	DO218908	SKCA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	0.8142
p.R740G	DO219881	SKCA	ICGC	PGTPPRE	DEG_SCF_FBW7_2	0.6457
p.P738L	SIDM00078	Oral Cavity Carcinoma	GDSC	PGTPPRE	DEG_SCF_FBW7_2	0.7582
p.E731D	SIDM00251	Gastric Carcinoma	GDSC	PGTPPRE	DEG_SCF_FBW7_2	0.2222
p.E731D	ACH-000949	Gastric Cancer	CCLE	PGTPPRE	DEG_SCF_FBW7_2	0.2222
p.G748S	SIDM00996	Thyroid Gland Carcinoma	GDSC	PGTPPRE	DEG_SCF_FBW7_2	0.1389
p.E731K	ACH-000740	Head and Neck Cancer	CCLE	PGTPPRE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXD9	Caskin-1	DEG_SCF_FBW7_2	735:741	PGTPPRE	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons