DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LPPYQE
Uniprot ID:
A2AJT9
Source protein:
BCLAF1 and THRAP3 family member 3
Source gene:
BCLAF3
Class:
LIG_APCC_ABBA_1
Location:
244:249
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9936
ASA_SCORE:
97.4333
COIL:
0.9122
CONS_SCORE:
0.6663
DSS_SCORE:
0.6306
HELIX:
0.0687
FCONS_SCORE:
1.1301
RIG_SCORE:
0.6346
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D252V
SIDM00285
Neuroblastoma
GDSC
LPPYQE
LIG_APCC_ABBA_1
0.25
p.D252V
CHP-134
autonomic_ganglia
COSMIC
LPPYQE
LIG_APCC_ABBA_1
0.25
Drug responses associated with BCLAF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPPYQE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A2AJT9
BCLAF1 and THRAP3 family member 3
LIG_APCC_ABBA_1
244:249
LPPYQE
APC,CDC20,FZR1
0.9936
More...