DegronMD

Uniprot ID: P10244

Source protein: Myb-related protein B

Source gene: MYBL2

Class: DEG_SCF_FBW7_2

Location: 535:542

E3 ligase: FBXW7

DEGRON score: 0.9894

ASA_SCORE: 79.9875

COIL: 0.6999

CONS_SCORE: 0.3278

DSS_SCORE: 0.538

HELIX: 0.2649

FCONS_SCORE: 0.985

RIG_SCORE: 0.7023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D544N	TCGA-3U-A98F	MESO	TCGA	LPQTPHLE	DEG_SCF_FBW7_2	0.2778
p.A525T	TCGA-BR-4184	STAD	TCGA	LPQTPHLE	DEG_SCF_FBW7_2	0.0556
p.S551Y	TCGA-FS-A1ZM	SKCM	TCGA	LPQTPHLE	DEG_SCF_FBW7_2	0.0833
p.A529S	DO19693	KIRC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.1667
p.D538Y	DO20368	KIRC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.7325
p.R551L	DO228971	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.0833
p.R540S	DO229006	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.7427
p.G530V	DO229008	LICA	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.1944
p.P541S	DO25020	LUAD	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.6752
p.L550P	DO26502	LUSC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.1111
p.R526H	DO229591	PRAD	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.0833
p.S527Y	DO37731	SKCM	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.1111
p.E532K	DO41020	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.25
p.E532K	DO52412	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.25
p.E532K	DO41524	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.25
p.E532K	DO42793	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.25
p.R552Q	DO42608	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.0556
p.R551W	DO41235	UCEC	ICGC	LPQTPHLE	DEG_SCF_FBW7_2	0.0833
p.K528N	ACH-000923	Lymphoma	CCLE	LPQTPHLE	DEG_SCF_FBW7_2	0.5833
p.R550C	ACH-000999	Colon/Colorectal Cancer	CCLE	LPQTPHLE	DEG_SCF_FBW7_2	0.1111
p.Y529C	ACH-001719	Ovarian Cancer	CCLE	LPQTPHLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10244	Myb-related protein B	DEG_SCF_FBW7_2	535:542	LPQTPHLE	FBXW7	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons