DegronMD

Uniprot ID: Q6UXY1

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Source gene: BAIAP2L2

Class: DEG_SCF_FBW7_1

Location: 294:301

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 84.9

COIL: 0.9145

CONS_SCORE: 0.6975

DSS_SCORE: 0.7012

HELIX: 0.0604

FCONS_SCORE: 1.5341

RIG_SCORE: 0.61

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S302L	DO222817	BTCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	0.3056
p.S301T	DO229253	THCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	0.7116
p.P298Q	DO229264	THCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	0.7035
p.R291S	DO229216	THCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	0.25
p.R292C	ACH-000990	Endometrial/Uterine Cancer	CCLE	LPRTPSAS	DEG_SCF_FBW7_1	0.2778
p.P295S	ACH-000998	Colon/Colorectal Cancer	CCLE	LPRTPSAS	DEG_SCF_FBW7_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXY1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	DEG_SCF_FBW7_1	294:301	LPRTPSAS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons