DegronMD - Q6UXY1(BAIAP2L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M399V	TCGA-17-Z043	LUAD	TCGA	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.M399V	TCGA-CV-5971	HNSC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.M399V	DO15150	HNSC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.M399V	SIDM00819	Kidney Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.M399V	ACH-002189	Kidney Cancer	CCLE	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.P392H	TCGA-AP-A051	UCEC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.25
p.P392H	DO42673	UCEC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.25
p.R529H	TCGA-BR-4361	STAD	TCGA	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8244
p.R529H	DO38887	STAD	ICGC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8244
p.V390M	TCGA-DF-A2KU	UCEC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1944
p.V390M	DO223286	UCEC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1944
p.M411I	TCGA-EY-A1GI	UCEC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.0556
p.M411I	DO41211	UCEC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.0556
p.S302L	DO222817	BTCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.3056
p.P395H	DO230312	COCA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.7694
p.V396M	DO222884	COCA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.V396M	DO51030	LAML	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6097
p.R529L	DO229003	COCA	ICGC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8428
p.R529L	SIDM00373	Endometrial Carcinoma	GDSC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8428
p.R529L	SIDM00607	Glioblastoma	GDSC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8428
p.R529L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8428
p.R529L	SIDM00381	Cervical Carcinoma	GDSC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8428
p.R529L	SIDM01446	Glioblastoma	GDSC	LIR	DEG_APCC_TPR_1	527:529	Mutation altering degron motif	0.8428
p.P398S	DO233938	GACA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.P398S	DO45195	LIRI	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S406T	DO51030	LAML	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1944
p.P389T	DO228952	LICA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1667
p.T518N	DO228976	LICA	ICGC	LIR	DEG_APCC_TPR_1	527:529	Mutation rewiring degron network	0.0833
p.P407S	DO227891	PBCA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1667
p.S301T	DO229253	THCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7116
p.P298Q	DO229264	THCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.7035
p.R291S	DO229216	THCA	ICGC	LPRTPSAS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.25
p.S401P	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S401P	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S401P	SIDM00819	Kidney Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S401P	SIDM00254	Neuroblastoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S401P	SIDM01749	Osteosarcoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S401P	SIDM01494	Glioblastoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.S401P	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6752
p.T400S	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation altering degron motif	0.6005
p.R523H	SIDM01173	Rhabdomyosarcoma	GDSC	LIR	DEG_APCC_TPR_1	527:529	Mutation rewiring degron network	0.2222
p.R523H	ACH-000772	Sarcoma	CCLE	LIR	DEG_APCC_TPR_1	527:529	Mutation rewiring degron network	0.2222
p.R523H	TE-441-T	soft tissue	COSMIC	LIR	DEG_APCC_TPR_1	527:529	Mutation rewiring degron network	0.2222
p.R292C	ACH-000990	Endometrial/Uterine Cancer	CCLE	LPRTPSAS	DEG_SCF_FBW7_1	294:301	Mutation rewiring degron network	0.2778
p.P295S	ACH-000998	Colon/Colorectal Cancer	CCLE	LPRTPSAS	DEG_SCF_FBW7_1	294:301	Mutation altering degron motif	0.5641
p.T409S	NCI-H522	lung	COSMIC	PVTPMTS	DEG_SCF_FBW7_1	395:401	Mutation rewiring degron network	0.1111

Kaplan plot for BAIAP2L2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAIAP2L2

UniProt ID: Q6UXY1

Entrez ID: 80115

Protein name: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (BAI1-associated protein 2-like protein 2) (Planar intestinal- and kidney-specific BAR domain protein) (Pinkbar)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAIAP2L2 in