DegronMD

Uniprot ID: Q6UXY1

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Source gene: BAIAP2L2

Class: DEG_SCF_FBW7_1

Location: 395:401

E3 ligase: FBXW7

DEGRON score: 0.9634

ASA_SCORE: 83.8857

COIL: 0.931

CONS_SCORE: 0.6322

DSS_SCORE: 0.5839

HELIX: 0.0396

FCONS_SCORE: 1.03

RIG_SCORE: 0.6941

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M399V	TCGA-17-Z043	LUAD	TCGA	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.M399V	TCGA-CV-5971	HNSC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.M399V	DO15150	HNSC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.M399V	SIDM00819	Kidney Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.M399V	ACH-002189	Kidney Cancer	CCLE	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.P392H	TCGA-AP-A051	UCEC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	0.25
p.P392H	DO42673	UCEC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.25
p.V390M	TCGA-DF-A2KU	UCEC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	0.1944
p.V390M	DO223286	UCEC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.1944
p.M411I	TCGA-EY-A1GI	UCEC	TCGA	PVTPMTS	DEG_SCF_FBW7_1	0.0556
p.M411I	DO41211	UCEC	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.0556
p.P395H	DO230312	COCA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.7694
p.V396M	DO222884	COCA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.V396M	DO51030	LAML	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.6097
p.P398S	DO233938	GACA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.P398S	DO45195	LIRI	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S406T	DO51030	LAML	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.1944
p.P389T	DO228952	LICA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.1667
p.P407S	DO227891	PBCA	ICGC	PVTPMTS	DEG_SCF_FBW7_1	0.1667
p.S401P	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S401P	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S401P	SIDM00819	Kidney Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S401P	SIDM00254	Neuroblastoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S401P	SIDM01749	Osteosarcoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S401P	SIDM01494	Glioblastoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.S401P	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6752
p.T400S	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PVTPMTS	DEG_SCF_FBW7_1	0.6005
p.T409S	NCI-H522	lung	COSMIC	PVTPMTS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTPMTS

Degron related mutations and impact score

Drug responses associated with BAIAP2L2 mutations

All proteins holding degron of PVTPMTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXY1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	DEG_SCF_FBW7_1	395:401	PVTPMTS	FBXW7	0.9634	More...