DegronMD

Uniprot ID: Q6UXY1

Source protein: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

Source gene: BAIAP2L2

Class: DEG_APCC_TPR_1

Location: 527:529

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9383

ASA_SCORE: 131.7

COIL: 0.9417

CONS_SCORE: 0.594

DSS_SCORE: 0.9122

HELIX: 0.0333

FCONS_SCORE: 0.8739

RIG_SCORE: 0.7913

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R529H	TCGA-BR-4361	STAD	TCGA	LIR	DEG_APCC_TPR_1	0.8244
p.R529H	DO38887	STAD	ICGC	LIR	DEG_APCC_TPR_1	0.8244
p.R529L	DO229003	COCA	ICGC	LIR	DEG_APCC_TPR_1	0.8428
p.R529L	SIDM00373	Endometrial Carcinoma	GDSC	LIR	DEG_APCC_TPR_1	0.8428
p.R529L	SIDM00607	Glioblastoma	GDSC	LIR	DEG_APCC_TPR_1	0.8428
p.R529L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LIR	DEG_APCC_TPR_1	0.8428
p.R529L	SIDM00381	Cervical Carcinoma	GDSC	LIR	DEG_APCC_TPR_1	0.8428
p.R529L	SIDM01446	Glioblastoma	GDSC	LIR	DEG_APCC_TPR_1	0.8428
p.T518N	DO228976	LICA	ICGC	LIR	DEG_APCC_TPR_1	0.0833
p.R523H	SIDM01173	Rhabdomyosarcoma	GDSC	LIR	DEG_APCC_TPR_1	0.2222
p.R523H	ACH-000772	Sarcoma	CCLE	LIR	DEG_APCC_TPR_1	0.2222
p.R523H	TE-441-T	soft_tissue	COSMIC	LIR	DEG_APCC_TPR_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	DEG_APCC_TPR_1	348:350	LIR	APC,CDC20,FZR1	0.8085	More...
Q6UXY1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	DEG_APCC_TPR_1	527:529	LIR	APC,CDC20,FZR1	0.9383	More...
Q9Y330	Zinc finger and BTB domain-containing protein 12	DEG_APCC_TPR_1	457:459	LIR	APC,CDC20,FZR1	0.8469	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons