DegronMD

Uniprot ID: Q07820

Source protein: Induced myeloid leukemia cell differentiation protein Mcl-1

Source gene: MCL1

Class: DEG_APCC_TPR_1

Location: 348:350

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8085

ASA_SCORE: 87.4667

COIL: 0.7893

CONS_SCORE: 0.759

DSS_SCORE: 0.3679

HELIX: 0.1907

FCONS_SCORE: 1.0839

RIG_SCORE: 0.9199

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G344V	SIDM01164	Glioma	GDSC	LIR	DEG_APCC_TPR_1	0.2222
p.G344V	ACH-000883	Brain Cancer	CCLE	LIR	DEG_APCC_TPR_1	0.2222
p.G344V	SW1783	central_nervous_system	COSMIC	LIR	DEG_APCC_TPR_1	0.2222

Drug responses associated with MCL1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01164	LGG\|glioma	p.G344V (Yes)	GDSC	Obatoclax Mesylate	0.2005
SIDM01164	LGG\|glioma	p.G344V (Yes)	GDSC	TW 37	0.2346
SIDM01164	LGG\|glioma	p.G344V (Yes)	GDSC	UMI-77	7.1388
SIDM01164	LGG\|glioma	p.G344V (Yes)	GDSC	MIM1	90.513
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	Obatoclax Mesylate	0.1771
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	TW 37	0.3407
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	Obatoclax Mesylate	0.6914
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	AZD5991	931.03
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	Sabutoclax	1.5322
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	UMI-77	8.5458
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	MIM1	16.643
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	Obatoclax Mesylate	3.9197
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	TW 37	0.6887
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	Obatoclax Mesylate	11.074
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	AZD5991	5.1498
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	Sabutoclax	1.8102
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	UMI-77	297.09
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	MIM1	45.502
SIDM00661	DLBC\|B_cell_lymphoma	p.N260S (No)	GDSC	Obatoclax Mesylate	0.2201
SIDM00661	DLBC\|B_cell_lymphoma	p.N260S (No)	GDSC	TW 37	0.5461
SIDM00040	STAD\|stomach	p.L141fs*92 (No)	GDSC	Obatoclax Mesylate	0.1778
SIDM00040	STAD\|stomach	p.L141fs*92 (No)	GDSC	TW 37	0.3493
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	Obatoclax Mesylate	4.4474
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	TW 37	0.2673
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	Obatoclax Mesylate	4.7534
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	AZD5991	19.725
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	Sabutoclax	0.227
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	UMI-77	14.497
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (No)	GDSC	MIM1	21.881
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	Obatoclax Mesylate	0.037
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	TW 37	0.835
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	Obatoclax Mesylate	0.5407
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	AZD5991	0.3119
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	Sabutoclax	0.1053
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	UMI-77	5.4162
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	MIM1	9.2393
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	Obatoclax Mesylate	0.037
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	TW 37	0.835
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	Obatoclax Mesylate	0.5407
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	AZD5991	0.3119
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	Sabutoclax	0.1053
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	UMI-77	5.4162
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	MIM1	9.2393
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	Obatoclax Mesylate	0.1032
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	TW 37	0.1809
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	Obatoclax Mesylate	1.8291
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	AZD5991	64.597
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	Sabutoclax	0.1159
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	UMI-77	15.634
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	MIM1	13.887
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	Obatoclax Mesylate	0.2044
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	TW 37	0.1496
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	Obatoclax Mesylate	2.888
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	AZD5991	0.2303
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	Sabutoclax	0.2689
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	UMI-77	8.4253
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	MIM1	20.807
SIDM00217	COREAD\|large_intestine	p.A193T (No)	GDSC	Obatoclax Mesylate	18.229
SIDM00217	COREAD\|large_intestine	p.A193T (No)	GDSC	AZD5991	3.2958
SIDM00217	COREAD\|large_intestine	p.A193T (No)	GDSC	Sabutoclax	1.2834
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	Obatoclax Mesylate	0.0177
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	TW 37	0.11
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	Obatoclax Mesylate	1.0045
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	AZD5991	0.0415
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	Sabutoclax	0.011
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	UMI-77	5.4205
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	MIM1	1.5205
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	Obatoclax Mesylate	0.0177
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	TW 37	0.11
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	Obatoclax Mesylate	1.0045
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	AZD5991	0.0415
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	Sabutoclax	0.011
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	UMI-77	5.4205
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	MIM1	1.5205
SIDM00283	DLBC\|B_cell_lymphoma	p.R263K (No)	GDSC	Obatoclax Mesylate	0.2061
SIDM00283	DLBC\|B_cell_lymphoma	p.R263K (No)	GDSC	TW 37	0.2628
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	Obatoclax Mesylate	0.154
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	TW 37	0.2612
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	Obatoclax Mesylate	6.6678
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	AZD5991	302.53
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	Sabutoclax	0.8102
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	UMI-77	10.354
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	MIM1	451.04

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	DEG_APCC_TPR_1	348:350	LIR	APC,CDC20,FZR1	0.8085	More...
Q6UXY1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	DEG_APCC_TPR_1	527:529	LIR	APC,CDC20,FZR1	0.9383	More...
Q9Y330	Zinc finger and BTB domain-containing protein 12	DEG_APCC_TPR_1	457:459	LIR	APC,CDC20,FZR1	0.8469	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIR

Degron related mutations and impact score

Drug responses associated with MCL1 mutations

All proteins holding degron of LIR