DegronMD - Q07820(MCL1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D218H	TCGA-06-2566	GBM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2222
p.D218H	DO11507	GBM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2222
p.T212I	TCGA-D3-A2J8	SKCM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation altering degron motif	0.5966
p.T212I	DO37778	SKCM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation altering degron motif	0.5966
p.V216G	TCGA-D3-A3C7	SKCM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.V216G	DO47569	SKCM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.H224N	TCGA-D3-A3C8	SKCM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556
p.H224N	DO47636	SKCM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556
p.D218N	TCGA-EJ-5542	PRAD	TCGA	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2222
p.D218N	DO36331	PRAD	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2222
p.T196R	TCGA-FD-A6TF	BLCA	TCGA	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556
p.T196R	DO51880	BLCA	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556
p.R215W	DO234365	ESAD	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.3056
p.P198A	DO224563	LUSC	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.1111
p.M199K	DO52686	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.1389
p.S206R	DO52686	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation altering degron motif	0.6316
p.R215Q	DO52675	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.3056
p.V216I	DO52675	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.2778
p.K197E	DO228451	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation blocking ubiquitination signal	0.5278
p.H224Y	DO52648	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556
p.G344V	SIDM01164	Glioma	GDSC	LIR	DEG_APCC_TPR_1	348:350	Mutation rewiring degron network	0.2222
p.G344V	ACH-000883	Brain Cancer	CCLE	LIR	DEG_APCC_TPR_1	348:350	Mutation rewiring degron network	0.2222
p.G344V	SW1783	central nervous system	COSMIC	LIR	DEG_APCC_TPR_1	348:350	Mutation rewiring degron network	0.2222
p.R215G	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.3056
p.R215G	ACH-000980	Lung Cancer	CCLE	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.3056
p.R215G	NCI-H1155	lung	COSMIC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.3056
p.H224R	SIDM01619	Endometrial Carcinoma	GDSC	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556
p.H224R	ACH-000984	Endometrial/Uterine Cancer	CCLE	SRKALETLR	DEG_APCC_DBOX_1	206:214	Mutation rewiring degron network	0.0556

Kaplan plot for MCL1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCL1

UniProt ID: Q07820

Entrez ID: 4170

Protein name: Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2-like protein 3) (Bcl2-L-3) (Bcl-2-related protein EAT/mcl1) (mcl1/EAT)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MCL1 in