DegronMD

Uniprot ID: Q07820

Source protein: Induced myeloid leukemia cell differentiation protein Mcl-1

Source gene: MCL1

Class: DEG_APCC_DBOX_1

Location: 206:214

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9089

ASA_SCORE: 52.3111

COIL: 0.0839

CONS_SCORE: 0.5754

DSS_SCORE: 0.5741

HELIX: 0.9149

FCONS_SCORE: 1.1836

RIG_SCORE: 0.7414

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D218H	TCGA-06-2566	GBM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	0.2222
p.D218H	DO11507	GBM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.2222
p.T212I	TCGA-D3-A2J8	SKCM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	0.5966
p.T212I	DO37778	SKCM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.5966
p.V216G	TCGA-D3-A3C7	SKCM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	0.2778
p.V216G	DO47569	SKCM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.2778
p.H224N	TCGA-D3-A3C8	SKCM	TCGA	SRKALETLR	DEG_APCC_DBOX_1	0.0556
p.H224N	DO47636	SKCM	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.0556
p.D218N	TCGA-EJ-5542	PRAD	TCGA	SRKALETLR	DEG_APCC_DBOX_1	0.2222
p.D218N	DO36331	PRAD	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.2222
p.T196R	TCGA-FD-A6TF	BLCA	TCGA	SRKALETLR	DEG_APCC_DBOX_1	0.0556
p.T196R	DO51880	BLCA	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.0556
p.R215W	DO234365	ESAD	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.3056
p.P198A	DO224563	LUSC	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.1111
p.M199K	DO52686	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.1389
p.S206R	DO52686	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.6316
p.R215Q	DO52675	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.3056
p.V216I	DO52675	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.2778
p.K197E	DO228451	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.5278
p.H224Y	DO52648	MALY	ICGC	SRKALETLR	DEG_APCC_DBOX_1	0.0556
p.R215G	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	SRKALETLR	DEG_APCC_DBOX_1	0.3056
p.R215G	ACH-000980	Lung Cancer	CCLE	SRKALETLR	DEG_APCC_DBOX_1	0.3056
p.R215G	NCI-H1155	lung	COSMIC	SRKALETLR	DEG_APCC_DBOX_1	0.3056
p.H224R	SIDM01619	Endometrial Carcinoma	GDSC	SRKALETLR	DEG_APCC_DBOX_1	0.0556
p.H224R	ACH-000984	Endometrial/Uterine Cancer	CCLE	SRKALETLR	DEG_APCC_DBOX_1	0.0556

Drug responses associated with MCL1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01164	LGG\|glioma	p.G344V (No)	GDSC	Obatoclax Mesylate	0.2005
SIDM01164	LGG\|glioma	p.G344V (No)	GDSC	TW 37	0.2346
SIDM01164	LGG\|glioma	p.G344V (No)	GDSC	UMI-77	7.1388
SIDM01164	LGG\|glioma	p.G344V (No)	GDSC	MIM1	90.513
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	Obatoclax Mesylate	0.1771
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	TW 37	0.3407
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	Obatoclax Mesylate	0.6914
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	AZD5991	931.03
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	Sabutoclax	1.5322
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	UMI-77	8.5458
SIDM00778	COREAD\|large_intestine	p.M231L (No)	GDSC	MIM1	16.643
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	Obatoclax Mesylate	3.9197
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	TW 37	0.6887
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	Obatoclax Mesylate	11.074
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	AZD5991	5.1498
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	Sabutoclax	1.8102
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	UMI-77	297.09
SIDM01045	UCEC\|endometrium	p.G18_A19insG (No)	GDSC	MIM1	45.502
SIDM00661	DLBC\|B_cell_lymphoma	p.N260S (No)	GDSC	Obatoclax Mesylate	0.2201
SIDM00661	DLBC\|B_cell_lymphoma	p.N260S (No)	GDSC	TW 37	0.5461
SIDM00040	STAD\|stomach	p.L141fs*92 (No)	GDSC	Obatoclax Mesylate	0.1778
SIDM00040	STAD\|stomach	p.L141fs*92 (No)	GDSC	TW 37	0.3493
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	Obatoclax Mesylate	4.4474
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	TW 37	0.2673
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	Obatoclax Mesylate	4.7534
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	AZD5991	19.725
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	Sabutoclax	0.227
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	UMI-77	14.497
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R215G (Yes)	GDSC	MIM1	21.881
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	Obatoclax Mesylate	0.037
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	TW 37	0.835
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	Obatoclax Mesylate	0.5407
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	AZD5991	0.3119
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	Sabutoclax	0.1053
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	UMI-77	5.4162
SIDM01007	ALL\|lymphoblastic_leukemia	p.D256N (No)	GDSC	MIM1	9.2393
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	Obatoclax Mesylate	0.037
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	TW 37	0.835
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	Obatoclax Mesylate	0.5407
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	AZD5991	0.3119
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	Sabutoclax	0.1053
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	UMI-77	5.4162
SIDM01007	ALL\|lymphoblastic_leukemia	p.D236Y (No)	GDSC	MIM1	9.2393
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	Obatoclax Mesylate	0.1032
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	TW 37	0.1809
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	Obatoclax Mesylate	1.8291
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	AZD5991	64.597
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	Sabutoclax	0.1159
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	UMI-77	15.634
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.M120V (No)	GDSC	MIM1	13.887
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	Obatoclax Mesylate	0.2044
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	TW 37	0.1496
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	Obatoclax Mesylate	2.888
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	AZD5991	0.2303
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	Sabutoclax	0.2689
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	UMI-77	8.4253
SIDM00211	ALL\|lymphoblastic_leukemia	p.M120V (No)	GDSC	MIM1	20.807
SIDM00217	COREAD\|large_intestine	p.A193T (No)	GDSC	Obatoclax Mesylate	18.229
SIDM00217	COREAD\|large_intestine	p.A193T (No)	GDSC	AZD5991	3.2958
SIDM00217	COREAD\|large_intestine	p.A193T (No)	GDSC	Sabutoclax	1.2834
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	Obatoclax Mesylate	0.0177
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	TW 37	0.11
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	Obatoclax Mesylate	1.0045
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	AZD5991	0.0415
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	Sabutoclax	0.011
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	UMI-77	5.4205
SIDM00406	DLBC\|B_cell_lymphoma	p.C248R (No)	GDSC	MIM1	1.5205
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	Obatoclax Mesylate	0.0177
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	TW 37	0.11
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	Obatoclax Mesylate	1.0045
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	AZD5991	0.0415
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	Sabutoclax	0.011
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	UMI-77	5.4205
SIDM00406	DLBC\|B_cell_lymphoma	p.Y15H (No)	GDSC	MIM1	1.5205
SIDM00283	DLBC\|B_cell_lymphoma	p.R263K (No)	GDSC	Obatoclax Mesylate	0.2061
SIDM00283	DLBC\|B_cell_lymphoma	p.R263K (No)	GDSC	TW 37	0.2628
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	Obatoclax Mesylate	0.154
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	TW 37	0.2612
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	Obatoclax Mesylate	6.6678
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	AZD5991	302.53
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	Sabutoclax	0.8102
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	UMI-77	10.354
SIDM01068	LUAD\|lung_NSCLC_adenocarcinoma	p.S247F (No)	GDSC	MIM1	451.04

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRKALETLR

Degron related mutations and impact score

Drug responses associated with MCL1 mutations

All proteins holding degron of SRKALETLR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	DEG_APCC_DBOX_1	206:214	SRKALETLR	APC,CDC20,FZR1	0.9089	More...