DegronMD

Uniprot ID: Q9Y330

Source protein: Zinc finger and BTB domain-containing protein 12

Source gene: ZBTB12

Class: DEG_APCC_TPR_1

Location: 457:459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8469

ASA_SCORE: 135.7333

COIL: 0.967

CONS_SCORE: 0.4018

DSS_SCORE: 0.6636

HELIX: 0.006

FCONS_SCORE: 0.7415

RIG_SCORE: 0.8801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R459C	TCGA-B5-A3FC	UCEC	TCGA	LIR	DEG_APCC_TPR_1	0.8301
p.R459C	DO41871	UCEC	ICGC	LIR	DEG_APCC_TPR_1	0.8301
p.E448V	TCGA-GD-A2C5	BLCA	TCGA	LIR	DEG_APCC_TPR_1	0.0833
p.E448V	DO496	BLCA	ICGC	LIR	DEG_APCC_TPR_1	0.0833
p.E448K	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	LIR	DEG_APCC_TPR_1	0.0833
p.E448K	ACH-002220	Lymphoma	CCLE	LIR	DEG_APCC_TPR_1	0.0833
p.E448K	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	LIR	DEG_APCC_TPR_1	0.0833
p.I458S	ACH-001190	Skin Cancer	CCLE	LIR	DEG_APCC_TPR_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	DEG_APCC_TPR_1	348:350	LIR	APC,CDC20,FZR1	0.8085	More...
Q6UXY1	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2	DEG_APCC_TPR_1	527:529	LIR	APC,CDC20,FZR1	0.9383	More...
Q9Y330	Zinc finger and BTB domain-containing protein 12	DEG_APCC_TPR_1	457:459	LIR	APC,CDC20,FZR1	0.8469	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons