DegronMD

Uniprot ID: Q86XK3

Source protein: Swi5-dependent recombination DNA repair protein 1 homolog

Source gene: SFR1

Class: DEG_SCF_FBW7_1

Location: 24:31

E3 ligase: FBXW7

DEGRON score: 0.9898

ASA_SCORE: 79.225

COIL: 0.9343

CONS_SCORE: 0.2827

DSS_SCORE: 0.6543

HELIX: 0.033

FCONS_SCORE: 0.9399

RIG_SCORE: 0.6119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S35L	TCGA-CF-A1HR	BLCA	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	0.2222
p.S35L	TCGA-CR-7379	HNSC	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	0.2222
p.P25H	TCGA-D3-A2JC	SKCM	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	0.6583
p.P17L	TCGA-YD-A89C	SKCM	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	0.1389
p.S22L	DO469	BLCA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.2778
p.S22L	DO14174	HNSC	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.2778
p.E40K	DO8898	COAD	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.0833
p.A16S	DO229026	LICA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.1111
p.E29A	DO50936	LICA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.7701
p.P21S	DO218855	SKCA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.25
p.M34I	DO37941	SKCM	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.25
p.R30Q	DO40884	UCEC	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.7329
p.A19T	DO42977	UCEC	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	0.1944
p.Q29R	SIDM00948	Burkitt's Lymphoma	GDSC	LPSTPQAS	DEG_SCF_FBW7_1	0.6218
p.Q29R	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LPSTPQAS	DEG_SCF_FBW7_1	0.6218
p.Q16R	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LPSTPQAS	DEG_SCF_FBW7_1	0.1111
p.R41I	HCC2998	large_intestine	COSMIC	LPSTPQAS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XK3	Swi5-dependent recombination DNA repair protein 1 homolog	DEG_SCF_FBW7_1	24:31	LPSTPQAS	FBXW7	0.9898	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons