DegronMD - Q86XK3(SFR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S35L	TCGA-CF-A1HR	BLCA	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.2222
p.S35L	TCGA-CR-7379	HNSC	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.2222
p.P25H	TCGA-D3-A2JC	SKCM	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.6583
p.P17L	TCGA-YD-A89C	SKCM	TCGA	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.1389
p.S22L	DO469	BLCA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.2778
p.S22L	DO14174	HNSC	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.2778
p.K180N	DO2401	BRCA	ICGC	RRLKLVKMY	DEG_APCC_DBOX_1	171:179	Mutation rewiring degron network	0.3056
p.K180N	DO41752	UCEC	ICGC	RRLKLVKMY	DEG_APCC_DBOX_1	171:179	Mutation rewiring degron network	0.3056
p.E40K	DO8898	COAD	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.0833
p.A141T	DO219892	DLBC	ICGC	DSGSCS	DEG_SCF_TRCP1_1	131:136	Mutation rewiring degron network	0.1944
p.A141S	DO228978	LICA	ICGC	DSGSCS	DEG_SCF_TRCP1_1	131:136	Mutation rewiring degron network	0.1944
p.A16S	DO229026	LICA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.1111
p.C122F	DO229031	LICA	ICGC	DSGSCS	DEG_SCF_TRCP1_1	131:136	Mutation rewiring degron network	0.0833
p.E29A	DO50936	LICA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.7701
p.P21S	DO218855	SKCA	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.25
p.M34I	DO37941	SKCM	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.25
p.R30Q	DO40884	UCEC	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.7329
p.K145N	DO43186	UCEC	ICGC	DSGSCS	DEG_SCF_TRCP1_1	131:136	Mutation rewiring degron network	0.0833
p.A19T	DO42977	UCEC	ICGC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.1944
p.Q29R	SIDM00948	Burkitt's Lymphoma	GDSC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.6218
p.Q29R	DG-75	haematopoietic and lymphoid tissue	COSMIC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation altering degron motif	0.6218
p.Q16R	DG-75	haematopoietic and lymphoid tissue	COSMIC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.1111
p.R41I	HCC2998	large intestine	COSMIC	LPSTPQAS	DEG_SCF_FBW7_1	24:31	Mutation rewiring degron network	0.0556

Kaplan plot for SFR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SFR1

UniProt ID: Q86XK3

Entrez ID: 119392

Protein name: Swi5-dependent recombination DNA repair protein 1 homolog (Meiosis protein 5 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SFR1 in