DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRLKLVKMY
Uniprot ID:
Q86XK3
Source protein:
Swi5-dependent recombination DNA repair protein 1 homolog
Source gene:
SFR1
Class:
DEG_APCC_DBOX_1
Location:
171:179
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5051
ASA_SCORE:
90.0889
COIL:
0.065
CONS_SCORE:
0.8328
DSS_SCORE:
0.1839
HELIX:
0.9298
FCONS_SCORE:
1.2823
RIG_SCORE:
0.8964
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K180N
DO2401
BRCA
ICGC
RRLKLVKMY
DEG_APCC_DBOX_1
0.3056
p.K180N
DO41752
UCEC
ICGC
RRLKLVKMY
DEG_APCC_DBOX_1
0.3056
Drug responses associated with SFR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRLKLVKMY
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86XK3
Swi5-dependent recombination DNA repair protein 1 homolog
DEG_APCC_DBOX_1
171:179
RRLKLVKMY
APC,CDC20,FZR1
0.5051
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