DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1331:1337

E3 ligase: FBXW7

DEGRON score: 0.7378

ASA_SCORE: 88.0571

COIL: 0.9381

CONS_SCORE: 0.2406

DSS_SCORE: 0.7482

HELIX: 0.0153

FCONS_SCORE: 0.8692

RIG_SCORE: 0.6398

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1347I	TCGA-56-6545	LUSC	TCGA	LPTPATS	DEG_SCF_FBW7_1	0.0556
p.T1347I	DO26532	LUSC	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.0556
p.P1334Q	TCGA-86-8073	LUAD	TCGA	LPTPATS	DEG_SCF_FBW7_1	0.7035
p.P1334Q	DO23624	LUAD	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.7035
p.T1342M	TCGA-A5-A0GH	UCEC	TCGA	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.T1342M	DO43634	UCEC	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.S1346L	TCGA-AG-A002	READ	TCGA	LPTPATS	DEG_SCF_FBW7_1	0.0833
p.S1346L	SIDM01051	Ovarian Carcinoma	GDSC	LPTPATS	DEG_SCF_FBW7_1	0.0833
p.S1346L	ACH-000936	Ovarian Cancer	CCLE	LPTPATS	DEG_SCF_FBW7_1	0.0833
p.S1346L	EFO-27	ovary	COSMIC	LPTPATS	DEG_SCF_FBW7_1	0.0833
p.T1330I	TCGA-AX-A2HD	UCEC	TCGA	LPTPATS	DEG_SCF_FBW7_1	0.3056
p.T1330I	DO42608	UCEC	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.3056
p.S1340G	TCGA-BR-8487	STAD	TCGA	LPTPATS	DEG_SCF_FBW7_1	0.25
p.S1340G	DO47867	STAD	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.25
p.R1326W	DO218693	GACA	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.R1326W	DO233272	GACA	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.T1333P	DO229506	SKCA	ICGC	LPTPATS	DEG_SCF_FBW7_1	0.7031
p.R1326Q	SIDM00545	Melanoma	GDSC	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.R1326Q	ACH-000987	Skin Cancer	CCLE	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.R1326Q	Mewo	skin	COSMIC	LPTPATS	DEG_SCF_FBW7_1	0.1944
p.P1344S	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPTPATS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1331:1337	LPTPATS	FBXW7	0.7378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons