DegronMD

Uniprot ID: Q9BTV6

Source protein: Diphthine methyltransferase

Source gene: DPH7

Class: DEG_SCF_FBW7_2

Location: 373:379

E3 ligase: FBXW7

DEGRON score: 0.9193

ASA_SCORE: 51.2286

COIL: 0.6696

CONS_SCORE: 0.2837

DSS_SCORE: 0.5488

HELIX: 0.0797

FCONS_SCORE: 1.0109

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T364M	TCGA-F5-6814	READ	TCGA	LPTPCHE	DEG_SCF_FBW7_2	0.0833
p.T364M	DO36556	READ	ICGC	LPTPCHE	DEG_SCF_FBW7_2	0.0833
p.P376H	TCGA-FI-A2F4	UCEC	TCGA	LPTPCHE	DEG_SCF_FBW7_2	0.7694
p.P376H	DO43434	UCEC	ICGC	LPTPCHE	DEG_SCF_FBW7_2	0.7694
p.H378Y	DO48366	BLCA	ICGC	LPTPCHE	DEG_SCF_FBW7_2	0.6118
p.N384K	DO229028	LICA	ICGC	LPTPCHE	DEG_SCF_FBW7_2	0.1944
p.L367M	DO229037	LICA	ICGC	LPTPCHE	DEG_SCF_FBW7_2	0.1667
p.G386R	DO46354	OV	ICGC	LPTPCHE	DEG_SCF_FBW7_2	0.1389
p.D366Y	SIDM00789	Colorectal Carcinoma	GDSC	LPTPCHE	DEG_SCF_FBW7_2	0.1389
p.D366Y	ACH-000997	Colon/Colorectal Cancer	CCLE	LPTPCHE	DEG_SCF_FBW7_2	0.1389
p.D366Y	ACH-001061	Colon/Colorectal Cancer	CCLE	LPTPCHE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BTV6	Diphthine methyltransferase	DEG_SCF_FBW7_2	373:379	LPTPCHE	FBXW7	0.9193	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons