DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SCF_FBW7_1

Location: 1793:1799

E3 ligase: FBXW7

DEGRON score: 0.8257

ASA_SCORE: 95.7571

COIL: 0.9169

CONS_SCORE: 0.2978

DSS_SCORE: 0.7127

HELIX: 0.011

FCONS_SCORE: 0.971

RIG_SCORE: 0.638

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1788S	TCGA-22-5472	LUSC	TCGA	LPTPFTT	DEG_SCF_FBW7_1	0.1944
p.A1788S	DO27421	LUSC	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1944
p.S1790N	TCGA-BR-A4QI	STAD	TCGA	LPTPFTT	DEG_SCF_FBW7_1	0.6944
p.S1790N	DO38523	STAD	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.6944
p.T1804A	TCGA-BS-A0UF	UCEC	TCGA	LPTPFTT	DEG_SCF_FBW7_1	0.1944
p.T1804A	DO41488	UCEC	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1944
p.T1795I	DO48360	BLCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.7078
p.T1807S	DO48360	BLCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.T1807S	DO222760	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.T1807S	DO222839	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.T1807S	DO50980	LAML	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.T1807S	DO51021	LAML	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.T1807S	DO51025	LAML	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.T1807S	DO52372	LUSC	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1111
p.P1794T	DO222866	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO229010	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO229013	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO229016	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO229003	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO229005	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO50980	LAML	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.P1794T	DO52357	LUSC	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.5919
p.T1806S	DO229010	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1389
p.T1806S	DO229013	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1389
p.T1806S	DO229016	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1389
p.T1806S	DO229003	COCA	ICGC	LPTPFTT	DEG_SCF_FBW7_1	0.1389
p.P1803H	SIDM00980	Gastric Carcinoma	GDSC	LPTPFTT	DEG_SCF_FBW7_1	0.2222
p.P1802S	SW837	large_intestine	COSMIC	LPTPFTT	DEG_SCF_FBW7_1	0.25
p.H1800R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LPTPFTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SCF_FBW7_1	1793:1799	LPTPFTT	FBXW7	0.8257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPFTT

Degron related mutations and impact score

Drug responses associated with MUC6 mutations

All proteins holding degron of LPTPFTT