DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 2907:2913

E3 ligase: FBXW7

DEGRON score: 0.8883

ASA_SCORE: 89.5286

COIL: 0.908

CONS_SCORE: 0

DSS_SCORE: 0.6139

HELIX: 0.0176

FCONS_SCORE: 0

RIG_SCORE: 0.6152

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2919E	TCGA-39-5034	LUSC	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.1667
p.D2919E	DO26854	LUSC	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.1667
p.G2911V	TCGA-60-2714	LUSC	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.6421
p.G2911V	DO26530	LUSC	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.6421
p.P2910H	TCGA-AX-A2HD	UCEC	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.7694
p.P2910H	DO42608	UCEC	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.7694
p.T2902N	TCGA-BS-A0UV	UCEC	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.1944
p.T2902N	DO42793	UCEC	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.1944
p.S2920L	TCGA-DK-A3IS	BLCA	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.1389
p.S2920L	DO566	BLCA	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.1389
p.S2906F	TCGA-EB-A3XF	SKCM	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.3056
p.S2906F	TCGA-GF-A6C9	SKCM	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.3056
p.S2906F	DO37437	SKCM	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.3056
p.S2906F	DO51254	SKCM	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.3056
p.I2917M	TCGA-IC-A6RE	ESCA	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.2222
p.D2919A	TCGA-WE-AAA0	SKCM	TCGA	LPTPGQS	DEG_SCF_FBW7_1	0.1667
p.D2919A	DO51294	SKCM	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.1667
p.K2903R	DO223149	ESCA	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.3333
p.L2914M	DO228866	LICA	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.3056
p.P2910L	DO229462	SKCA	ICGC	LPTPGQS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	2907:2913	LPTPGQS	FBXW7	0.8883	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons