DegronMD

Uniprot ID: Q702N8

Source protein: Xin actin-binding repeat-containing protein 1

Source gene: XIRP1

Class: DEG_SCF_FBW7_1

Location: 862:868

E3 ligase: FBXW7

DEGRON score: 0.9613

ASA_SCORE: 65.6857

COIL: 0.883

CONS_SCORE: 0.6323

DSS_SCORE: 0.6077

HELIX: 0.0207

FCONS_SCORE: 0.9348

RIG_SCORE: 0.6073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D875N	TCGA-17-Z022	LUAD	TCGA	LPTPGSS	DEG_SCF_FBW7_1	0.1389
p.P876H	TCGA-D3-A1Q1	SKCM	TCGA	LPTPGSS	DEG_SCF_FBW7_1	0.1111
p.P876H	DO37445	SKCM	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.1111
p.P876L	TCGA-G4-6586	COAD	TCGA	LPTPGSS	DEG_SCF_FBW7_1	0.1111
p.P876L	DO9698	COAD	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.1111
p.S867R	TCGA-X6-A7WB	SARC	TCGA	LPTPGSS	DEG_SCF_FBW7_1	0.6316
p.S867R	DO220314	SARC	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.6316
p.P859L	TCGA-XK-AAIW	PRAD	TCGA	LPTPGSS	DEG_SCF_FBW7_1	0.25
p.P859L	DO51407	PRAD	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.25
p.P859L	SIDM01664	Prostate Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	0.25
p.P865T	DO233804	GACA	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.7031
p.P863S	DO229055	LICA	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.5641
p.E872K	DO49113	PACA	ICGC	LPTPGSS	DEG_SCF_FBW7_1	0.2222
p.R861K	SIDM00683	Prostate Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	0.3056
p.R861K	ACH-000977	lymph_node	CCLE	LPTPGSS	DEG_SCF_FBW7_1	0.3056
p.R861K	LNCaP-Clone-FGC	prostate	COSMIC	LPTPGSS	DEG_SCF_FBW7_1	0.3056
p.D875V	SIDM00564	Ovarian Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	0.1389
p.D875V	ACH-000527	Ovarian Cancer	CCLE	LPTPGSS	DEG_SCF_FBW7_1	0.1389
p.D875V	ACH-001611	Brain Cancer	CCLE	LPTPGSS	DEG_SCF_FBW7_1	0.1389
p.D875V	OVISE	ovary	COSMIC	LPTPGSS	DEG_SCF_FBW7_1	0.1389
p.P876A	SIDM01318	Hepatocellular Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	0.1111
p.Q856R	ACH-001033	Unknown	CCLE	LPTPGSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q702N8	Xin actin-binding repeat-containing protein 1	DEG_SCF_FBW7_1	862:868	LPTPGSS	FBXW7	0.9613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons