DegronMD - Q702N8(XIRP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D875N	TCGA-17-Z022	LUAD	TCGA	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1389
p.K1077N	TCGA-A5-A1OF	UCEC	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation substituting flanking lysine	0.3611
p.K1077N	DO42568	UCEC	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation substituting flanking lysine	0.3611
p.K1095N	TCGA-AA-A00N	COAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation substituting flanking lysine	0.1667
p.K1095N	DO9876	COAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation substituting flanking lysine	0.1667
p.Q1078H	TCGA-C5-A8XH	CESC	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.2778
p.Q1078H	DO49898	CESC	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.2778
p.G1092C	TCGA-CN-4729	HNSC	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092C	DO16029	HNSC	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092C	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092C	ACH-001599	Lung Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092C	NCI-H64	lung	COSMIC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.P876H	TCGA-D3-A1Q1	SKCM	TCGA	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1111
p.P876H	DO37445	SKCM	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1111
p.G1092S	TCGA-EE-A2MD	SKCM	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092S	TCGA-IB-AAUM	PAAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092S	DO222434	MELA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092S	DO51697	PAAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.G1092S	DO37851	SKCM	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1389
p.R1094Q	TCGA-ER-A194	SKCM	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.0833
p.R1094Q	TCGA-XK-AAIW	PRAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.0833
p.R1094Q	DO51407	PRAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.0833
p.R1094Q	DO47646	SKCM	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.0833
p.P876L	TCGA-G4-6586	COAD	TCGA	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1111
p.P876L	DO9698	COAD	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1111
p.S867R	TCGA-X6-A7WB	SARC	TCGA	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation altering degron motif	0.6316
p.S867R	DO220314	SARC	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation altering degron motif	0.6316
p.P859L	TCGA-XK-AAIW	PRAD	TCGA	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.25
p.P859L	DO51407	PRAD	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.25
p.P859L	SIDM01664	Prostate Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.25
p.L1093P	DO225386	BRCA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1111
p.P865T	DO233804	GACA	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation altering degron motif	0.7031
p.N1087I	DO228921	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.2778
p.P1088T	DO228952	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.25
p.Q1071K	DO228976	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.0833
p.N1074K	DO229022	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.1667
p.H1076Q	DO229026	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.2222
p.Q1078K	DO229032	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.2778
p.H1076N	DO229035	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.2222
p.T1081N	DO229038	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation altering degron motif	0.7055
p.P863S	DO229055	LICA	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation altering degron motif	0.5641
p.E872K	DO49113	PACA	ICGC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.2222
p.Q1070R	DO50426	PRAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.0556
p.R861K	SIDM00683	Prostate Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.3056
p.R861K	ACH-000977	lymph node	CCLE	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.3056
p.R861K	LNCaP-Clone-FGC	prostate	COSMIC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.3056
p.P1088L	SIDM00080	Melanoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.25
p.P1088L	ACH-000730	Skin Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.25
p.P1088L	SK-MEL-5	skin	COSMIC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation rewiring degron network	0.25
p.T1085S	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation altering degron motif	0.6005
p.T1085S	ACH-000664	Lymphoma	CCLE	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation altering degron motif	0.6005
p.T1085S	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation altering degron motif	0.6005
p.D875V	SIDM00564	Ovarian Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1389
p.D875V	ACH-000527	Ovarian Cancer	CCLE	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1389
p.D875V	ACH-001611	Brain Cancer	CCLE	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1389
p.D875V	OVISE	ovary	COSMIC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1389
p.P876A	SIDM01318	Hepatocellular Carcinoma	GDSC	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1111
p.Q856R	ACH-001033	Unknown	CCLE	LPTPGSS	DEG_SCF_FBW7_1	862:868	Mutation rewiring degron network	0.1667
p.T1083P	HCC38	breast	COSMIC	PTPTAT	DEG_SCF_FBW7_1	1080:1085	Mutation altering degron motif	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XIRP1

UniProt ID: Q702N8

Entrez ID: 165904

Protein name: Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XIRP1 in