DegronMD

Uniprot ID: Q702N8

Source protein: Xin actin-binding repeat-containing protein 1

Source gene: XIRP1

Class: DEG_SCF_FBW7_1

Location: 1080:1085

E3 ligase: FBXW7

DEGRON score: 0.7998

ASA_SCORE: 92.7

COIL: 0.9582

CONS_SCORE: 0.635

DSS_SCORE: 0.7598

HELIX: 0.0182

FCONS_SCORE: 0.9861

RIG_SCORE: 0.6057

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1077N	TCGA-A5-A1OF	UCEC	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.3611
p.K1077N	DO42568	UCEC	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.3611
p.K1095N	TCGA-AA-A00N	COAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.1667
p.K1095N	DO9876	COAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1667
p.Q1078H	TCGA-C5-A8XH	CESC	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.2778
p.Q1078H	DO49898	CESC	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.2778
p.G1092C	TCGA-CN-4729	HNSC	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092C	DO16029	HNSC	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092C	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092C	ACH-001599	Lung Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092C	NCI-H64	lung	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092S	TCGA-EE-A2MD	SKCM	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092S	TCGA-IB-AAUM	PAAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092S	DO222434	MELA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092S	DO51697	PAAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.G1092S	DO37851	SKCM	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.R1094Q	TCGA-ER-A194	SKCM	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.R1094Q	TCGA-XK-AAIW	PRAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.R1094Q	DO51407	PRAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.R1094Q	DO47646	SKCM	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.L1093P	DO225386	BRCA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1111
p.N1087I	DO228921	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.2778
p.P1088T	DO228952	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.25
p.Q1071K	DO228976	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.N1074K	DO229022	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1667
p.H1076Q	DO229026	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.2222
p.Q1078K	DO229032	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.2778
p.H1076N	DO229035	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.2222
p.T1081N	DO229038	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.7055
p.Q1070R	DO50426	PRAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.P1088L	SIDM00080	Melanoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	0.25
p.P1088L	ACH-000730	Skin Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	0.25
p.P1088L	SK-MEL-5	skin	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.25
p.T1085S	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	0.6005
p.T1085S	ACH-000664	Lymphoma	CCLE	PTPTAT	DEG_SCF_FBW7_1	0.6005
p.T1085S	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.6005
p.T1083P	HCC38	breast	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37198	Nuclear pore glycoprotein p62	DEG_SCF_FBW7_1	208:213	PTPTAT	FBXW7	0.9942	More...
Q702N8	Xin actin-binding repeat-containing protein 1	DEG_SCF_FBW7_1	1080:1085	PTPTAT	FBXW7	0.7998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPTAT

Degron related mutations and impact score

Drug responses associated with XIRP1 mutations

All proteins holding degron of PTPTAT