DegronMD

Uniprot ID: P37198

Source protein: Nuclear pore glycoprotein p62

Source gene: NUP62

Class: DEG_SCF_FBW7_1

Location: 208:213

E3 ligase: FBXW7

DEGRON score: 0.9942

ASA_SCORE: 78.55

COIL: 0.8915

CONS_SCORE: 0.3579

DSS_SCORE: 0.5956

HELIX: 0.0377

FCONS_SCORE: 0.8819

RIG_SCORE: 0.7079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I214V	TCGA-56-5897	LUSC	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.3056
p.I214V	DO26453	LUSC	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.3056
p.A223E	TCGA-AA-A01R	COAD	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.A223E	DO7934	COAD	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.A212V	TCGA-AB-2828	LAML	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.5825
p.A212V	DO21571	LAML	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.5825
p.Q204R	TCGA-CC-A5UD	LIHC	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.2222
p.Q204R	DO219552	LIHC	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.2222
p.G218E	TCGA-EB-A3XD	SKCM	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.1944
p.G218E	DO37871	SKCM	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1944
p.A212T	TCGA-EY-A215	UCEC	TCGA	PTPTAT	DEG_SCF_FBW7_1	0.6028
p.A212T	DO42665	UCEC	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.6028
p.G201V	DO229053	LICA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.1389
p.A212G	DO233293	NACA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.6429
p.A223V	DO233294	NACA	ICGC	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.A223V	SIDM00217	Colorectal Carcinoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.A223V	ACH-000999	Colon/Colorectal Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.A223V	SNU-1040	large_intestine	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.0556
p.S216N	SIDM00491	Thyroid Gland Carcinoma	GDSC	PTPTAT	DEG_SCF_FBW7_1	0.25
p.S216N	ACH-001443	Thyroid Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	0.25
p.S216N	ASH-3	thyroid	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.25
p.F222S	SIDM00785	Acute Myeloid Leukemia	GDSC	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.F222S	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPTAT	DEG_SCF_FBW7_1	0.0833
p.L221F	ACH-001521	Skin Cancer	CCLE	PTPTAT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37198	Nuclear pore glycoprotein p62	DEG_SCF_FBW7_1	208:213	PTPTAT	FBXW7	0.9942	More...
Q702N8	Xin actin-binding repeat-containing protein 1	DEG_SCF_FBW7_1	1080:1085	PTPTAT	FBXW7	0.7998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons