DegronMD

Uniprot ID: Q5VYJ5

Source protein: MAM and LDL-receptor class A domain-containing protein 1

Source gene: MALRD1

Class: DEG_SCF_FBW7_1

Location: 1033:1039

E3 ligase: FBXW7

DEGRON score: 0.9798

ASA_SCORE: 78.3143

COIL: 0.937

CONS_SCORE: 0.499

DSS_SCORE: 0.5397

HELIX: 0.0149

FCONS_SCORE: 1.1843

RIG_SCORE: 0.6616

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1029F	SIDM00299	Other Sarcomas	GDSC	LPTPPET	DEG_SCF_FBW7_1	0.2222
p.L1029F	MFH-ino	soft_tissue	COSMIC	LPTPPET	DEG_SCF_FBW7_1	0.2222
p.E1045V	TCGA-AY-A69D	COAD	TCGA	LPTPPET	DEG_SCF_FBW7_1	0.1667
p.P1026T	SIDM00967	Ovarian Carcinoma	GDSC	LPTPPET	DEG_SCF_FBW7_1	0.1389
p.P1026T	SIDM00454	Rhabdomyosarcoma	GDSC	LPTPPET	DEG_SCF_FBW7_1	0.1389
p.P1026T	SIDM00656	Burkitt's Lymphoma	GDSC	LPTPPET	DEG_SCF_FBW7_1	0.1389
p.P1026T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LPTPPET	DEG_SCF_FBW7_1	0.1389
p.P1026T	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LPTPPET	DEG_SCF_FBW7_1	0.1389

Showing 1 to 8 of 8 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VYJ5	MAM and LDL-receptor class A domain-containing protein 1	DEG_SCF_FBW7_1	1033:1039	LPTPPET	FBXW7	0.9798	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons