DegronMD

Uniprot ID: Q9Y6K0

Source protein: Choline/ethanolaminephosphotransferase 1

Source gene: CEPT1

Class: DEG_SCF_FBW7_1

Location: 38:44

E3 ligase: FBXW7

DEGRON score: 0.7411

ASA_SCORE: 57.8143

COIL: 0.962

CONS_SCORE: 0.5186

DSS_SCORE: 0.3771

HELIX: 0.0134

FCONS_SCORE: 0.9379

RIG_SCORE: 0.7312

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R50W	TCGA-2W-A8YY	CESC	TCGA	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50W	TCGA-EY-A1GK	UCEC	TCGA	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50W	TCGA-VQ-A8P2	STAD	TCGA	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50W	DO223732	CESC	ICGC	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50W	DO51761	STAD	ICGC	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50W	DO42985	UCEC	ICGC	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50Q	TCGA-2W-A8YY	CESC	TCGA	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.R50Q	DO223732	CESC	ICGC	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.T28I	TCGA-HU-A4GH	STAD	TCGA	LPTPPLS	DEG_SCF_FBW7_1	0.0556
p.T28I	DO47743	STAD	ICGC	LPTPPLS	DEG_SCF_FBW7_1	0.0556
p.R45T	DO46438	OV	ICGC	LPTPPLS	DEG_SCF_FBW7_1	0.3056
p.T40I	SIDM01006	Plasma Cell Myeloma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T40I	SIDM00399	Head and Neck Carcinoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T40I	SIDM00659	Glioblastoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T40I	SIDM00676	Bladder Carcinoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.8189
p.T40I	SIDM01615	Non-Small Cell Lung Carcinoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.8189
p.R45K	SIDM00135	Breast Carcinoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.3056
p.R45K	ACH-000148	Breast Cancer	CCLE	LPTPPLS	DEG_SCF_FBW7_1	0.3056
p.R45K	Hs-578-T	breast	COSMIC	LPTPPLS	DEG_SCF_FBW7_1	0.3056
p.L32I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.L32I	ACH-000843	Lung Cancer	CCLE	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.L32I	HARA	lung	COSMIC	LPTPPLS	DEG_SCF_FBW7_1	0.1667
p.S44P	SIDM01088	Endometrial Carcinoma	GDSC	LPTPPLS	DEG_SCF_FBW7_1	0.7863
p.S44P	RL95-2	endometrium	COSMIC	LPTPPLS	DEG_SCF_FBW7_1	0.7863

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6K0	Choline/ethanolaminephosphotransferase 1	DEG_SCF_FBW7_1	38:44	LPTPPLS	FBXW7	0.7411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons