DegronMD

Uniprot ID: Q5VU43

Source protein: Myomegalin

Source gene: PDE4DIP

Class: DEG_SCF_FBW7_1

Location: 1678:1684

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 102.5

COIL: 0.956

CONS_SCORE: 0.5642

DSS_SCORE: 0.7601

HELIX: 0.023

FCONS_SCORE: 1.0003

RIG_SCORE: 0.6029

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1669D	TCGA-22-4593	LUSC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.0833
p.I1676V	TCGA-2W-A8YY	CESC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.2778
p.I1676V	TCGA-37-3789	LUSC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.2778
p.S1673N	TCGA-2W-A8YY	CESC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.6389
p.S1673T	TCGA-44-8119	LUAD	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.6389
p.A1688T	TCGA-AP-A1DK	UCEC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.2222
p.L1678F	TCGA-BR-8591	STAD	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.6981
p.L1678F	TCGA-EO-A3AU	UCEC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.6981
p.S1693L	TCGA-EB-A97M	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.0833
p.E1670K	TCGA-EE-A2GO	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.1111
p.E1670K	TCGA-Z2-AA3V	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.1111
p.E1670K	TCGA-ZH-A8Y5	CHOL	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.1111
p.E1670K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	0.1111
p.E1670K	SIDM01525	Acute Myeloid Leukemia	GDSC	LPTPQNT	DEG_SCF_FBW7_1	0.1111
p.E1687K	TCGA-EO-A22U	UCEC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.25
p.A1669V	TCGA-FS-A4F0	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.0833
p.P1681L	TCGA-RP-A694	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.7582
p.P1681T	TCGA-VD-A8KL	UVM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	0.7031
p.P1684L	DO51948	BLCA	ICGC	LPTPQNT	DEG_SCF_FBW7_1	0.7582
p.D1688N	DO222527	MELA	ICGC	LPTPQNT	DEG_SCF_FBW7_1	0.2222
p.P1675S	SIDM00084	Glioblastoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	0.25
p.P1675S	SF295	central_nervous_system	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.25
p.E1670Q	SIDM00183	Small Cell Lung Carcinoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	0.1111
p.Q1682H	SIDM00488	Colorectal Carcinoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	0.647
p.Q1682H	ACH-002345	Colon/Colorectal Cancer	CCLE	LPTPQNT	DEG_SCF_FBW7_1	0.647
p.Q1682H	CaR-1	large_intestine	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.647
p.S1691G	ACH-000130	Leukemia	CCLE	LPTPQNT	DEG_SCF_FBW7_1	0.1389
p.P1675T	ACH-000566	Bladder Cancer	CCLE	LPTPQNT	DEG_SCF_FBW7_1	0.25
p.K1693R	ACH-000987	Skin Cancer	CCLE	LPTPQNT	DEG_SCF_FBW7_1	0.0833
p.K1693R	Mewo	skin	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.0833
p.P1685R	NCI-H661	lung	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.3056
p.A1688V	SNU-C2B	large_intestine	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.2222
p.S1671C	NCI-H2135	lung	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.5833
p.G1691V	SNU-81	large_intestine	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.1389
p.L1675F	LNCaP-Clone-FGC	prostate	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPQNT

Degron related mutations and impact score

Drug responses associated with PDE4DIP mutations

All proteins holding degron of LPTPQNT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VU43	Myomegalin	DEG_SCF_FBW7_1	1678:1684	LPTPQNT	FBXW7	0.9933	More...