DegronMD - Q5VU43(PDE4DIP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1669D	TCGA-22-4593	LUSC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.0833
p.A1669D	TCGA-22-4593	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1389
p.E391K	TCGA-22-5479	LUSC	TCGA	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.0833
p.E391K	DO27287	LUSC	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.0833
p.I1676V	TCGA-2W-A8YY	CESC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.2778
p.I1676V	TCGA-37-3789	LUSC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.2778
p.S1673N	TCGA-2W-A8YY	CESC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation blocking phosphorylation signal	0.6389
p.S1673T	TCGA-44-8119	LUAD	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation blocking phosphorylation signal	0.6389
p.S1655F	TCGA-86-8358	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.25
p.K753R	TCGA-94-A5I6	LUSC	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.25
p.K753R	DO219176	LUSC	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.25
p.S1648L	TCGA-A5-A0GP	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0556
p.S1648L	TCGA-W3-AA1R	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0556
p.S1648L	SIDM01617	Endometrial Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.0556
p.K732R	TCGA-AA-3977	COAD	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.2778
p.K732R	DO8730	COAD	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.2778
p.A1688T	TCGA-AP-A1DK	UCEC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.2222
p.S1664F	TCGA-AP-A1DV	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2778
p.S1660L	TCGA-BH-A0B6	BRCA	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation altering degron motif	0.7667
p.L1678F	TCGA-BR-8591	STAD	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.6981
p.L1678F	TCGA-EO-A3AU	UCEC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.6981
p.T730N	TCGA-D5-6928	COAD	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1111
p.T730N	DO7776	COAD	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1111
p.S1693L	TCGA-EB-A97M	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.0833
p.E1670K	TCGA-EE-A2GO	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1111
p.E1670K	TCGA-EE-A2GO	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.E1670K	TCGA-Z2-AA3V	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1111
p.E1670K	TCGA-Z2-AA3V	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.E1670K	TCGA-ZH-A8Y5	CHOL	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1111
p.E1670K	TCGA-ZH-A8Y5	CHOL	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.E1670K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1111
p.E1670K	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.E1670K	SIDM01525	Acute Myeloid Leukemia	GDSC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1111
p.E1670K	SIDM01525	Acute Myeloid Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.S393F	TCGA-EE-A3AD	SKCM	TCGA	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.S393F	DO37707	SKCM	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.E1687K	TCGA-EO-A22U	UCEC	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.25
p.A1669V	TCGA-FS-A4F0	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.0833
p.A1669V	TCGA-FS-A4F0	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1389
p.P1681L	TCGA-RP-A694	SKCM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.7582
p.S740F	TCGA-V5-A7RB	ESCA	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7982
p.P1681T	TCGA-VD-A8KL	UVM	TCGA	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.7031
p.S393C	TCGA-XF-AAMG	BLCA	TCGA	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.S393C	DO219049	BLCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.P1684L	DO51948	BLCA	ICGC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.7582
p.H735Y	DO581	BLCA	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.25
p.R733Q	DO7801	COAD	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1944
p.R733Q	DO219771	UCEC	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1944
p.T747I	DO222492	COCA	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation blocking phosphorylation signal	0.75
p.E410V	DO229010	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2778
p.E410V	DO229013	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2778
p.E410V	DO229016	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2778
p.E410V	DO229003	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2778
p.E410V	DO229005	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2778
p.L1662F	DO223070	ESCA	ICGC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation altering degron motif	0.6981
p.L404S	DO233747	GACA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7667
p.V1654A	DO10880	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2222
p.D1688N	DO222527	MELA	ICGC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.2222
p.K753I	DO51518	PACA	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation substituting flanking lysine	0.25
p.P1656S	DO219501	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2778
p.D1666N	DO42280	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2222
p.D1666E	DO41488	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2222
p.P1675S	SIDM00084	Glioblastoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.25
p.P1675S	SF295	central nervous system	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.25
p.E1670Q	SIDM00183	Small Cell Lung Carcinoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1111
p.E1670Q	SIDM00183	Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.1111
p.Q1682H	SIDM00488	Colorectal Carcinoma	GDSC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.647
p.Q1682H	ACH-002345	Colon/Colorectal Cancer	CCLE	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.647
p.Q1682H	CaR-1	large intestine	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation altering degron motif	0.647
p.Q406P	SIDM01609	Endometrial Carcinoma	GDSC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.5924
p.S1691G	ACH-000130	Leukemia	CCLE	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1389
p.P1675T	ACH-000566	Bladder Cancer	CCLE	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.25
p.K741N	ACH-000676	Brain Cancer	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.6918
p.K741N	ACH-002389	Neuroblastoma	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.6918
p.K741N	ACN	autonomic ganglia	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.6918
p.R1654M	ACH-000979	Prostate Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2222
p.R1654M	DU-145	prostate	COSMIC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.2222
p.K1693R	ACH-000987	Skin Cancer	CCLE	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.0833
p.K1693R	Mewo	skin	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.0833
p.P744Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7035
p.S1665R	ACH-001016	Brain Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.25
p.S1665R	Becker	central nervous system	COSMIC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.25
p.K415Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.K415Q	HCC2998	large intestine	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.H738N	ACH-001485	Leukemia	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7423
p.S403N	ACH-001845	Bile Duct Cancer	CCLE	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.7069
p.S415T	ACH-002129	Lung Cancer	CCLE	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.S415T	H2731	pleura	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.1389
p.L750P	HCT-116	large intestine	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222
p.L411S	KU812	haematopoietic and lymphoid tissue	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.25
p.L411S	HuP-T3	pancreas	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.25
p.L1662M	MCC13	skin	COSMIC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation altering degron motif	0.711
p.K410T	CS1	bone	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.2778
p.K737E	CW-2	large intestine	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.3056
p.R739G	HUTU-80	small intestine	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation altering degron motif	0.7568
p.G750A	NCI-H187	lung	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222
p.R756H	SCH	stomach	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.0556
p.P1685R	NCI-H661	lung	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.3056
p.K391N	ACN	autonomic ganglia	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.0833
p.R734C	SNU-387	liver	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222
p.R734C	HSC-4	upper aerodigestive tract	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.2222
p.A1688V	SNU-C2B	large intestine	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.2222
p.R747C	C-33-A	cervix	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation blocking phosphorylation signal	0.75
p.T730S	SC-1	haematopoietic and lymphoid tissue	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1111
p.S1671C	NCI-H2135	lung	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation blocking phosphorylation signal	0.5833
p.S1671C	NCI-H2135	lung	COSMIC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation blocking phosphorylation signal	0.5278
p.G1691V	SNU-81	large intestine	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.1389
p.R406H	SCH	stomach	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.8244
p.E401Q	NCI-H187	lung	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation altering degron motif	0.6744
p.A1657S	RKO	large intestine	COSMIC	PSSTS	DEG_SPOP_SBC_1	1658:1662	Mutation rewiring degron network	0.3056
p.E751Q	NCI-H187	lung	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	738:746	Mutation rewiring degron network	0.1944
p.R409Q	22RV1	prostate	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	400:408	Mutation rewiring degron network	0.3056
p.L1675F	LNCaP-Clone-FGC	prostate	COSMIC	LPTPQNT	DEG_SCF_FBW7_1	1678:1684	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE4DIP

UniProt ID: Q5VU43

Entrez ID: 9659

Protein name: Myomegalin (Cardiomyopathy-associated protein 2) (Phosphodiesterase 4D-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE4DIP in