DegronMD

Uniprot ID: Q5VU43

Source protein: Myomegalin

Source gene: PDE4DIP

Class: DEG_APCC_DBOX_1

Location: 738:746

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9934

ASA_SCORE: 98.0778

COIL: 0.683

CONS_SCORE: 0.6074

DSS_SCORE: 0.4605

HELIX: 0.3049

FCONS_SCORE: 1.0473

RIG_SCORE: 0.7182

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K753R	TCGA-94-A5I6	LUSC	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	0.25
p.K753R	DO219176	LUSC	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.25
p.K732R	TCGA-AA-3977	COAD	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	0.2778
p.K732R	DO8730	COAD	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.2778
p.T730N	TCGA-D5-6928	COAD	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	0.1111
p.T730N	DO7776	COAD	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.1111
p.S740F	TCGA-V5-A7RB	ESCA	TCGA	PRSTLGDLD	DEG_APCC_DBOX_1	0.7982
p.H735Y	DO581	BLCA	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.25
p.R733Q	DO7801	COAD	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.1944
p.R733Q	DO219771	UCEC	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.1944
p.T747I	DO222492	COCA	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.75
p.K753I	DO51518	PACA	ICGC	PRSTLGDLD	DEG_APCC_DBOX_1	0.25
p.K741N	ACH-000676	Brain Cancer	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	0.6918
p.K741N	ACH-002389	Neuroblastoma	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	0.6918
p.K741N	ACN	autonomic_ganglia	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.6918
p.P744Q	ACH-000990	Endometrial/Uterine Cancer	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	0.7035
p.H738N	ACH-001485	Leukemia	CCLE	PRSTLGDLD	DEG_APCC_DBOX_1	0.7423
p.L750P	HCT-116	large_intestine	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.2222
p.K737E	CW-2	large_intestine	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.3056
p.R739G	HUTU-80	small_intestine	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.7568
p.G750A	NCI-H187	lung	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.2222
p.R756H	SCH	stomach	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.0556
p.R734C	SNU-387	liver	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.2222
p.R734C	HSC-4	upper_aerodigestive_tract	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.2222
p.R747C	C-33-A	cervix	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.75
p.T730S	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.1111
p.E751Q	NCI-H187	lung	COSMIC	PRSTLGDLD	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSTLGDLD

Degron related mutations and impact score

Drug responses associated with PDE4DIP mutations

All proteins holding degron of PRSTLGDLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VU43	Myomegalin	DEG_APCC_DBOX_1	738:746	PRSTLGDLD	APC,CDC20,FZR1	0.9934	More...