DegronMD

Uniprot ID: Q5VU43

Source protein: Myomegalin

Source gene: PDE4DIP

Class: DEG_APCC_DBOX_1

Location: 400:408

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6041

ASA_SCORE: 102.3667

COIL: 0.0139

CONS_SCORE: 0.6758

DSS_SCORE: 0.4433

HELIX: 0.9867

FCONS_SCORE: 1.0839

RIG_SCORE: 0.7748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E391K	TCGA-22-5479	LUSC	TCGA	LRKALQQLQ	DEG_APCC_DBOX_1	0.0833
p.E391K	DO27287	LUSC	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.0833
p.S393F	TCGA-EE-A3AD	SKCM	TCGA	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.S393F	DO37707	SKCM	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.S393C	TCGA-XF-AAMG	BLCA	TCGA	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.S393C	DO219049	BLCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.E410V	DO229010	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.2778
p.E410V	DO229013	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.2778
p.E410V	DO229016	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.2778
p.E410V	DO229003	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.2778
p.E410V	DO229005	COCA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.2778
p.L404S	DO233747	GACA	ICGC	LRKALQQLQ	DEG_APCC_DBOX_1	0.7667
p.Q406P	SIDM01609	Endometrial Carcinoma	GDSC	LRKALQQLQ	DEG_APCC_DBOX_1	0.5924
p.K415Q	ACH-001081	Colon/Colorectal Cancer	CCLE	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.K415Q	HCC2998	large_intestine	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.S403N	ACH-001845	Bile Duct Cancer	CCLE	LRKALQQLQ	DEG_APCC_DBOX_1	0.7069
p.S415T	ACH-002129	Lung Cancer	CCLE	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.S415T	H2731	pleura	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.1389
p.L411S	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.25
p.L411S	HuP-T3	pancreas	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.25
p.K410T	CS1	bone	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.2778
p.K391N	ACN	autonomic_ganglia	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.0833
p.R406H	SCH	stomach	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.8244
p.E401Q	NCI-H187	lung	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.6744
p.R409Q	22RV1	prostate	COSMIC	LRKALQQLQ	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VU43	Myomegalin	DEG_APCC_DBOX_1	400:408	LRKALQQLQ	APC,CDC20,FZR1	0.6041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRKALQQLQ

Degron related mutations and impact score

Drug responses associated with PDE4DIP mutations

All proteins holding degron of LRKALQQLQ