DegronMD

Uniprot ID: Q9NPC7

Source protein: Myoneurin

Source gene: MYNN

Class: DEG_SCF_FBW7_2

Location: 218:224

E3 ligase: FBXW7

DEGRON score: 0.864

ASA_SCORE: 76.6571

COIL: 0.7321

CONS_SCORE: 0.4174

DSS_SCORE: 0.284

HELIX: 0.163

FCONS_SCORE: 0.8486

RIG_SCORE: 0.8121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S233L	TCGA-BP-4964	KIRC	TCGA	LPTPVVE	DEG_SCF_FBW7_2	0.0833
p.S233L	DO16263	KIRC	ICGC	LPTPVVE	DEG_SCF_FBW7_2	0.0833
p.D214H	TCGA-PG-A914	UCEC	TCGA	LPTPVVE	DEG_SCF_FBW7_2	0.2222
p.D214H	DO52421	UCEC	ICGC	LPTPVVE	DEG_SCF_FBW7_2	0.2222
p.V222L	DO229038	LICA	ICGC	LPTPVVE	DEG_SCF_FBW7_2	0.5654
p.N216D	DO48697	LIRI	ICGC	LPTPVVE	DEG_SCF_FBW7_2	0.2778
p.A215E	SIDM00324	Neuroblastoma	GDSC	LPTPVVE	DEG_SCF_FBW7_2	0.25
p.A215E	ACH-001674	Neuroblastoma	CCLE	LPTPVVE	DEG_SCF_FBW7_2	0.25
p.A215E	TGW	autonomic_ganglia	COSMIC	LPTPVVE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPC7	Myoneurin	DEG_SCF_FBW7_2	218:224	LPTPVVE	FBXW7	0.864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons