DegronMD

Uniprot ID: A1A5C7

Source protein: Solute carrier family 22 member 23

Source gene: SLC22A23

Class: DEG_SCF_FBW7_1

Location: 155:162

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 55.9875

COIL: 0.847

CONS_SCORE: 0.4305

DSS_SCORE: 0.5846

HELIX: 0.0884

FCONS_SCORE: 1.2309

RIG_SCORE: 0.7837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P156T	TCGA-AP-A1DO	UCEC	TCGA	LPTTPFAT	DEG_SCF_FBW7_1	0.5919
p.P156T	DO43250	UCEC	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.5919
p.N151K	TCGA-DM-A280	COAD	TCGA	LPTTPFAT	DEG_SCF_FBW7_1	0.2222
p.N151K	DO8256	COAD	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.2222
p.A168E	DO229018	LICA	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.1667
p.A167D	DO229028	LICA	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.1944
p.G150R	DO228308	MALY	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.1944
p.G150R	ACH-001228		CCLE	LPTTPFAT	DEG_SCF_FBW7_1	0.1944
p.P159L	DO37440	SKCM	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.7582
p.P159S	DO37440	SKCM	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	0.6752
p.S154G	SIDM00901	Endometrial Carcinoma	GDSC	LPTTPFAT	DEG_SCF_FBW7_1	0.3056
p.G162R	SW48	large_intestine	COSMIC	LPTTPFAT	DEG_SCF_FBW7_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1A5C7	Solute carrier family 22 member 23	DEG_SCF_FBW7_1	155:162	LPTTPFAT	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons