DegronMD - A1A5C7(SLC22A23)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P156T	TCGA-AP-A1DO	UCEC	TCGA	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation altering degron motif	0.5919
p.P156T	DO43250	UCEC	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation altering degron motif	0.5919
p.R638C	TCGA-CD-8536	STAD	TCGA	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.719
p.R638C	TCGA-VQ-A91X	STAD	TCGA	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.719
p.N151K	TCGA-DM-A280	COAD	TCGA	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.2222
p.N151K	DO8256	COAD	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.2222
p.S631Y	TCGA-E6-A1M0	UCEC	TCGA	NGEHYTRQP	CBL_PTK	632:640	Mutation rewiring degron network	0.3056
p.P627L	TCGA-ER-A3ET	SKCM	TCGA	NGEHYTRQP	CBL_PTK	632:640	Mutation rewiring degron network	0.1944
p.G633E	TCGA-FR-A726	SKCM	TCGA	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.6087
p.A168E	DO229018	LICA	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.1667
p.A167D	DO229028	LICA	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.1944
p.H643N	DO229045	LICA	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation rewiring degron network	0.25
p.G150R	DO228308	MALY	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.1944
p.G150R	ACH-001228		CCLE	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.1944
p.N637I	DO229479	SKCA	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.728
p.P635L	DO37459	SKCM	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.7582
p.P159L	DO37440	SKCM	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation altering degron motif	0.7582
p.P159S	DO37440	SKCM	ICGC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation altering degron motif	0.6752
p.G641E	DO48665	SKCM	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation rewiring degron network	0.3056
p.R646C	DO51790	STAD	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation substituting flanking lysine	0.2778
p.R646C	DO47827	STAD	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation substituting flanking lysine	0.2778
p.S639Y	DO43682	UCEC	ICGC	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.712
p.E634K	SIDM00140	Melanoma	GDSC	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.591
p.E634K	ACH-000968	Skin Cancer	CCLE	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.591
p.E634K	COLO-792	skin	COSMIC	NGEHYTRQP	CBL_PTK	632:640	Mutation altering degron motif	0.591
p.S154G	SIDM00901	Endometrial Carcinoma	GDSC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation rewiring degron network	0.3056
p.G162R	SW48	large intestine	COSMIC	LPTTPFAT	DEG_SCF_FBW7_1	155:162	Mutation altering degron motif	0.7568
p.E642K	COLO-792	skin	COSMIC	NGEHYTRQP	CBL_PTK	632:640	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC22A23

UniProt ID: A1A5C7

Entrez ID: 63027

Protein name: Solute carrier family 22 member 23

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SLC22A23 in