DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NGEHYTRQP
Uniprot ID:
A1A5C7
Source protein:
Solute carrier family 22 member 23
Source gene:
SLC22A23
Class:
CBL_PTK
Location:
632:640
E3 ligase:
CBL
DEGRON score:
0.775
ASA_SCORE:
76.9444
COIL:
0.591
CONS_SCORE:
0.735
DSS_SCORE:
0.5028
HELIX:
0.395
FCONS_SCORE:
1.1486
RIG_SCORE:
0.6897
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R638C
TCGA-CD-8536
STAD
TCGA
NGEHYTRQP
CBL_PTK
0.719
p.R638C
TCGA-VQ-A91X
STAD
TCGA
NGEHYTRQP
CBL_PTK
0.719
p.S631Y
TCGA-E6-A1M0
UCEC
TCGA
NGEHYTRQP
CBL_PTK
0.3056
p.P627L
TCGA-ER-A3ET
SKCM
TCGA
NGEHYTRQP
CBL_PTK
0.1944
p.G633E
TCGA-FR-A726
SKCM
TCGA
NGEHYTRQP
CBL_PTK
0.6087
p.H643N
DO229045
LICA
ICGC
NGEHYTRQP
CBL_PTK
0.25
p.N637I
DO229479
SKCA
ICGC
NGEHYTRQP
CBL_PTK
0.728
p.P635L
DO37459
SKCM
ICGC
NGEHYTRQP
CBL_PTK
0.7582
p.G641E
DO48665
SKCM
ICGC
NGEHYTRQP
CBL_PTK
0.3056
p.R646C
DO51790
STAD
ICGC
NGEHYTRQP
CBL_PTK
0.2778
p.R646C
DO47827
STAD
ICGC
NGEHYTRQP
CBL_PTK
0.2778
p.S639Y
DO43682
UCEC
ICGC
NGEHYTRQP
CBL_PTK
0.712
p.E634K
SIDM00140
Melanoma
GDSC
NGEHYTRQP
CBL_PTK
0.591
p.E634K
ACH-000968
Skin Cancer
CCLE
NGEHYTRQP
CBL_PTK
0.591
p.E634K
COLO-792
skin
COSMIC
NGEHYTRQP
CBL_PTK
0.591
p.E642K
COLO-792
skin
COSMIC
NGEHYTRQP
CBL_PTK
0.2778
Drug responses associated with SLC22A23 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGEHYTRQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1A5C7
Solute carrier family 22 member 23
CBL_PTK
632:640
NGEHYTRQP
CBL
0.775
More...
