DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LPVHPD
Uniprot ID:
Q9UKL3
Source protein:
CASP8-associated protein 2
Source gene:
CASP8AP2
Class:
LIG_APCC_ABBA_1
Location:
1396:1401
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9122
ASA_SCORE:
72.8
COIL:
0.741
CONS_SCORE:
0.7632
DSS_SCORE:
0.2945
HELIX:
0.224
FCONS_SCORE:
1.043
RIG_SCORE:
0.7185
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CASP8AP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LPVHPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKL3
CASP8-associated protein 2
LIG_APCC_ABBA_1
1396:1401
LPVHPD
APC,CDC20,FZR1
0.9122
More...