DegronMD

Uniprot ID: Q92545

Source protein: Transmembrane protein 131

Source gene: TMEM131

Class: DEG_SCF_FBW7_2

Location: 1487:1494

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 87.0125

COIL: 0.8674

CONS_SCORE: 0.3668

DSS_SCORE: 0.6166

HELIX: 0.084

FCONS_SCORE: 1.1072

RIG_SCORE: 0.6999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1490N	TCGA-DU-6392	LGG	TCGA	LPYTPPLE	DEG_SCF_FBW7_2	0.8166
p.T1490N	DO22237	LGG	ICGC	LPYTPPLE	DEG_SCF_FBW7_2	0.8166
p.S1503N	TCGA-FW-A3TU	SKCM	TCGA	LPYTPPLE	DEG_SCF_FBW7_2	0.0833
p.S1503N	DO37441	SKCM	ICGC	LPYTPPLE	DEG_SCF_FBW7_2	0.0833
p.P1477S	TCGA-W3-AA1R	SKCM	TCGA	LPYTPPLE	DEG_SCF_FBW7_2	0.0556
p.P1477S	DO51275	SKCM	ICGC	LPYTPPLE	DEG_SCF_FBW7_2	0.0556
p.P1488T	DO231954	LICA	ICGC	LPYTPPLE	DEG_SCF_FBW7_2	0.5919
p.P1502T	DO229027	LICA	ICGC	LPYTPPLE	DEG_SCF_FBW7_2	0.1111
p.S1483N	DO218861	SKCA	ICGC	LPYTPPLE	DEG_SCF_FBW7_2	0.2222
p.R1499S	SIDM00386	Ewing's Sarcoma	GDSC	LPYTPPLE	DEG_SCF_FBW7_2	0.1944
p.R1499S	SIDM00515	Melanoma	GDSC	LPYTPPLE	DEG_SCF_FBW7_2	0.1944
p.R1499S	ACH-000391	Bone Cancer	CCLE	LPYTPPLE	DEG_SCF_FBW7_2	0.1944
p.R1499S	MHH-ES-1	bone	COSMIC	LPYTPPLE	DEG_SCF_FBW7_2	0.1944
p.R1499S	COLO-800	skin	COSMIC	LPYTPPLE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92545	Transmembrane protein 131	DEG_SCF_FBW7_2	1487:1494	LPYTPPLE	FBXW7	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons