DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_SCF_FBW7_1

Location: 1111:1118

E3 ligase: FBXW7

DEGRON score: 0.9435

ASA_SCORE: 90.5

COIL: 0.9576

CONS_SCORE: 0.4795

DSS_SCORE: 0.6765

HELIX: 0.0168

FCONS_SCORE: 0.7597

RIG_SCORE: 0.6278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1101H	TCGA-AX-A1C9	UCEC	TCGA	LPYTPPSS	DEG_SCF_FBW7_1	0.0556
p.R1101H	DO43098	UCEC	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	0.0556
p.I1109M	TCGA-CA-6717	COAD	TCGA	LPYTPPSS	DEG_SCF_FBW7_1	0.2778
p.I1109M	DO8264	COAD	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	0.2778
p.S1117F	TCGA-EE-A2MR	SKCM	TCGA	LPYTPPSS	DEG_SCF_FBW7_1	0.6871
p.S1117F	DO37819	SKCM	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	0.6871
p.P1112S	DO45229	LIRI	ICGC	LPYTPPSS	DEG_SCF_FBW7_1	0.5641
p.P1112S	SIDM01047	Chronic Myelogenous Leukemia	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	0.5641
p.P1112S	ACH-000295	Leukemia	CCLE	LPYTPPSS	DEG_SCF_FBW7_1	0.5641
p.P1112S	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	LPYTPPSS	DEG_SCF_FBW7_1	0.5641
p.D1123N	SIDM00866	Breast Carcinoma	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	0.1944
p.D1123N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	0.1944
p.D1123N	SIDM00868	Non-Cancerous	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	0.1944
p.D1123N	ACH-000374	Breast Cancer	CCLE	LPYTPPSS	DEG_SCF_FBW7_1	0.1944
p.D1123N	ACH-000766	Lung Cancer	CCLE	LPYTPPSS	DEG_SCF_FBW7_1	0.1944
p.H1122R	SIDM01394	Kidney Carcinoma	GDSC	LPYTPPSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SCF_FBW7_1	1111:1118	LPYTPPSS	FBXW7	0.9435	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons