DegronMD

Uniprot ID: Q8NFP4

Source protein: MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Source gene: MDGA1

Class: SCF_FBXL2

Location: 461:470

E3 ligase: FBXL2

DEGRON score: 0.6425

ASA_SCORE: 66.82

COIL: 0.4739

CONS_SCORE: 0.9762

DSS_SCORE: 0.465

HELIX: 0.0009

FCONS_SCORE: 1.0456

RIG_SCORE: 0.7366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V478M	TCGA-D3-A51G	SKCM	TCGA	LQCEVRGKPR	SCF_FBXL2	0.1111
p.V478M	DO47700	SKCM	ICGC	LQCEVRGKPR	SCF_FBXL2	0.1111
p.V473E	TCGA-DM-A1HB	COAD	TCGA	LQCEVRGKPR	SCF_FBXL2	0.25
p.R466W	DO220484	KICH	ICGC	LQCEVRGKPR	SCF_FBXL2	0.8634
p.R454S	DO229041	LICA	ICGC	LQCEVRGKPR	SCF_FBXL2	0.1389
p.L461M	DO229008	LICA	ICGC	LQCEVRGKPR	SCF_FBXL2	0.711
p.T452I	DO38731	STAD	ICGC	LQCEVRGKPR	SCF_FBXL2	0.0833
p.L474R	DO229264	THCA	ICGC	LQCEVRGKPR	SCF_FBXL2	0.2222
p.C463R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LQCEVRGKPR	SCF_FBXL2	0.719
p.L461P	SIDM01617	Endometrial Carcinoma	GDSC	LQCEVRGKPR	SCF_FBXL2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFP4	MAM domain-containing glycosylphosphatidylinositol anchor protein 1	SCF_FBXL2	461:470	LQCEVRGKPR	FBXL2	0.6425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons