DegronMD

Uniprot ID: O75899

Source protein: Gamma-aminobutyric acid type B receptor subunit 2

Source gene: GABBR2

Class: DEG_SCF_FBW7_1

Location: 816:823

E3 ligase: FBXW7

DEGRON score: 0.5177

ASA_SCORE: 93.925

COIL: 0.6588

CONS_SCORE: 0.2869

DSS_SCORE: 0.4578

HELIX: 0.3128

FCONS_SCORE: 0.9453

RIG_SCORE: 0.7683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P820T	TCGA-91-8496	LUAD	TCGA	LQDTPEKT	DEG_SCF_FBW7_1	0.7031
p.P820T	DO45379	LUAD	ICGC	LQDTPEKT	DEG_SCF_FBW7_1	0.7031
p.E821Q	TCGA-IR-A3LH	CESC	TCGA	LQDTPEKT	DEG_SCF_FBW7_1	0.5633
p.E821Q	DO44381	CESC	ICGC	LQDTPEKT	DEG_SCF_FBW7_1	0.5633
p.I826T	DO222455	ESCA	ICGC	LQDTPEKT	DEG_SCF_FBW7_1	0.25
p.E811D	DO50780	LIRI	ICGC	LQDTPEKT	DEG_SCF_FBW7_1	0.1944
p.T824I	SIDM01169	Ovarian Carcinoma	GDSC	LQDTPEKT	DEG_SCF_FBW7_1	0.3056
p.T824I	ACH-000885	Ovarian Cancer	CCLE	LQDTPEKT	DEG_SCF_FBW7_1	0.3056
p.T824I	TOV-21G	ovary	COSMIC	LQDTPEKT	DEG_SCF_FBW7_1	0.3056
p.D808Y	SIDM00193	Colorectal Carcinoma	GDSC	LQDTPEKT	DEG_SCF_FBW7_1	0.1111
p.D808Y	ACH-000991	Colon/Colorectal Cancer	CCLE	LQDTPEKT	DEG_SCF_FBW7_1	0.1111
p.D808Y	SNU-81	large_intestine	COSMIC	LQDTPEKT	DEG_SCF_FBW7_1	0.1111
p.E833K	ACH-001061	Colon/Colorectal Cancer	CCLE	LQDTPEKT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75899	Gamma-aminobutyric acid type B receptor subunit 2	DEG_SCF_FBW7_1	816:823	LQDTPEKT	FBXW7	0.5177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons