DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
LQEAQRGR
Uniprot ID:
Q9H6A9
Source protein:
Pecanex-like protein 3
Source gene:
PCNX3
Class:
SCF_FBXL2
Location:
612:619
E3 ligase:
FBXL2
DEGRON score:
0.6657
ASA_SCORE:
97.2375
COIL:
0.4094
CONS_SCORE:
0.3928
DSS_SCORE:
0.6878
HELIX:
0.5823
FCONS_SCORE:
0.9804
RIG_SCORE:
0.6242
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PCNX3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LQEAQRGR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H6A9
Pecanex-like protein 3
SCF_FBXL2
612:619
LQEAQRGR
FBXL2
0.6657
More...
